DegronMD

Uniprot ID: Q15011

Source protein: Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

Source gene: HERPUD1

Class: DEG_APCC_DBOX_1

Location: 127:135

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9624

ASA_SCORE: 75.1333

COIL: 0.7091

CONS_SCORE: 0.3512

DSS_SCORE: 0.561

HELIX: 0.2046

FCONS_SCORE: 0.923

RIG_SCORE: 0.7186

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S136Y	TCGA-12-0778	GBM	TCGA	QREVLRNLS	DEG_APCC_DBOX_1	0.3056
p.E118D	TCGA-B9-4117	KIRP	TCGA	QREVLRNLS	DEG_APCC_DBOX_1	0.0833
p.R132W	TCGA-EI-6917	READ	TCGA	QREVLRNLS	DEG_APCC_DBOX_1	0.7523
p.S120F	TCGA-W3-AA1O	SKCM	TCGA	QREVLRNLS	DEG_APCC_DBOX_1	0.1389
p.E121Q	DO48399	BLCA	ICGC	QREVLRNLS	DEG_APCC_DBOX_1	0.1667
p.Y140C	DO219030	BLCA	ICGC	QREVLRNLS	DEG_APCC_DBOX_1	0.1944
p.G141W	DO228900	LICA	ICGC	QREVLRNLS	DEG_APCC_DBOX_1	0.1667
p.P132L	DO220891	MELA	ICGC	QREVLRNLS	DEG_APCC_DBOX_1	0.7582
p.G136S	DO218960	PAAD	ICGC	QREVLRNLS	DEG_APCC_DBOX_1	0.3056
p.P137L	SIDM01617	Endometrial Carcinoma	GDSC	QREVLRNLS	DEG_APCC_DBOX_1	0.2778
p.P137L	ACH-000994	Endometrial/Uterine Cancer	CCLE	QREVLRNLS	DEG_APCC_DBOX_1	0.2778
p.H145R	IGROV-1	ovary	COSMIC	QREVLRNLS	DEG_APCC_DBOX_1	0.0556
p.S135Y	ESO51	oesophagus	COSMIC	QREVLRNLS	DEG_APCC_DBOX_1	0.712

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15011	Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein	DEG_APCC_DBOX_1	127:135	QREVLRNLS	APC,CDC20,FZR1	0.9624	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons