DegronMD

Uniprot ID: Q15723

Source protein: ETS-related transcription factor Elf-2

Source gene: ELF2

Class: DEG_APCC_DBOX_1

Location: 273:281

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7053

ASA_SCORE: 73.7

COIL: 0.6656

CONS_SCORE: 0.9084

DSS_SCORE: 0.08

HELIX: 0.1361

FCONS_SCORE: 1.0128

RIG_SCORE: 0.8708

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V274A	TCGA-AA-3672	COAD	TCGA	QRGILAKVE	DEG_APCC_DBOX_1	0.6936
p.L265I	TCGA-AP-A1E0	UCEC	TCGA	QRGILAKVE	DEG_APCC_DBOX_1	0.1111
p.L265I	TCGA-F5-6814	READ	TCGA	QRGILAKVE	DEG_APCC_DBOX_1	0.1111
p.L273I	TCGA-DX-A6YV	SARC	TCGA	QRGILAKVE	DEG_APCC_DBOX_1	0.7174
p.P281L	TCGA-EO-A22R	UCEC	TCGA	QRGILAKVE	DEG_APCC_DBOX_1	0.7582
p.S276F	DO50403	ESAD	ICGC	QRGILAKVE	DEG_APCC_DBOX_1	0.7982
p.A291E	DO229019	LICA	ICGC	QRGILAKVE	DEG_APCC_DBOX_1	0.0556
p.V277F	DO25995	LUAD	ICGC	QRGILAKVE	DEG_APCC_DBOX_1	0.7068
p.N282H	DO50291	SKCM	ICGC	QRGILAKVE	DEG_APCC_DBOX_1	0.3056
p.N282H	DO219773	UCEC	ICGC	QRGILAKVE	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15723	ETS-related transcription factor Elf-2	DEG_APCC_DBOX_1	273:281	QRGILAKVE	APC,CDC20,FZR1	0.7053	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons