DegronMD

Uniprot ID: Q8NCW6

Source protein: Polypeptide N-acetylgalactosaminyltransferase 11

Source gene: GALNT11

Class: DEG_APCC_DBOX_1

Location: 481:489

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6094

ASA_SCORE: 59.4556

COIL: 0.3129

CONS_SCORE: 0.5058

DSS_SCORE: 0.4046

HELIX: 0.0137

FCONS_SCORE: 1.0725

RIG_SCORE: 0.7991

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R482L	TCGA-17-Z052	LUAD	TCGA	QRGRLYHLQ	DEG_APCC_DBOX_1	0.8428
p.K492R	TCGA-AA-3811	COAD	TCGA	QRGRLYHLQ	DEG_APCC_DBOX_1	0.3611
p.K492R	DO7962	COAD	ICGC	QRGRLYHLQ	DEG_APCC_DBOX_1	0.3611
p.G473V	DO228948	LICA	ICGC	QRGRLYHLQ	DEG_APCC_DBOX_1	0.1111
p.Q497K	DO35723	PBCA	ICGC	QRGRLYHLQ	DEG_APCC_DBOX_1	0.1111
p.L488V	ACH-002397	Thyroid Cancer	CCLE	QRGRLYHLQ	DEG_APCC_DBOX_1	0.5654
p.L488V	KMH-2	thyroid	COSMIC	QRGRLYHLQ	DEG_APCC_DBOX_1	0.5654

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NCW6	Polypeptide N-acetylgalactosaminyltransferase 11	DEG_APCC_DBOX_1	481:489	QRGRLYHLQ	APC,CDC20,FZR1	0.6094	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons