DegronMD

Uniprot ID: Q14139

Source protein: Ubiquitin conjugation factor E4 A

Source gene: UBE4A

Class: DEG_APCC_DBOX_1

Location: 89:97

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6084

ASA_SCORE: 31.6

COIL: 0.3436

CONS_SCORE: 0.3837

DSS_SCORE: 0.1556

HELIX: 0.5026

FCONS_SCORE: 1.4288

RIG_SCORE: 0.9083

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H86Y	TCGA-21-1082	LUSC	TCGA	QRIFLITLD	DEG_APCC_DBOX_1	0.25
p.H86Y	DO26463	LUSC	ICGC	QRIFLITLD	DEG_APCC_DBOX_1	0.25
p.P101H	TCGA-EE-A2GT	SKCM	TCGA	QRIFLITLD	DEG_APCC_DBOX_1	0.2222
p.P101H	DO36556	READ	ICGC	QRIFLITLD	DEG_APCC_DBOX_1	0.2222
p.P101H	DO37946	SKCM	ICGC	QRIFLITLD	DEG_APCC_DBOX_1	0.2222
p.I91F	DO223442	CLLE	ICGC	QRIFLITLD	DEG_APCC_DBOX_1	0.6304
p.C79F	DO229027	LICA	ICGC	QRIFLITLD	DEG_APCC_DBOX_1	0.0556
p.E80D	DO229037	LICA	ICGC	QRIFLITLD	DEG_APCC_DBOX_1	0.0833
p.D106N	HCT-15	large_intestine	COSMIC	QRIFLITLD	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14139	Ubiquitin conjugation factor E4 A	DEG_APCC_DBOX_1	89:97	QRIFLITLD	APC,CDC20,FZR1	0.6084	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons