DegronMD

Uniprot ID: Q9BT09

Source protein: Protein canopy homolog 3

Source gene: CNPY3

Class: DEG_APCC_DBOX_1

Location: 245:253

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9942

ASA_SCORE: 103.9444

COIL: 0.7864

CONS_SCORE: 0.2302

DSS_SCORE: 0.8185

HELIX: 0.1656

FCONS_SCORE: 1.0433

RIG_SCORE: 0.5544

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E253G	TCGA-17-Z023	LUAD	TCGA	QRKELGGLE	DEG_APCC_DBOX_1	0.6087
p.G238S	TCGA-AC-A2QH	BRCA	TCGA	QRKELGGLE	DEG_APCC_DBOX_1	0.1389
p.G238S	DO2061	BRCA	ICGC	QRKELGGLE	DEG_APCC_DBOX_1	0.1389
p.P258L	TCGA-EE-A2MS	SKCM	TCGA	QRKELGGLE	DEG_APCC_DBOX_1	0.1944
p.P258L	DO37567	SKCM	ICGC	QRKELGGLE	DEG_APCC_DBOX_1	0.1944
p.D261Y	DO229015	LICA	ICGC	QRKELGGLE	DEG_APCC_DBOX_1	0.1111
p.E248K	DO218855	SKCA	ICGC	QRKELGGLE	DEG_APCC_DBOX_1	0.591
p.G263D	SIDM00447	B-Lymphoblastic Leukemia	GDSC	QRKELGGLE	DEG_APCC_DBOX_1	0.0556
p.G263D	ACH-000960	Leukemia	CCLE	QRKELGGLE	DEG_APCC_DBOX_1	0.0556
p.G263D	REH	haematopoietic_and_lymphoid_tissue	COSMIC	QRKELGGLE	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BT09	Protein canopy homolog 3	DEG_APCC_DBOX_1	245:253	QRKELGGLE	APC,CDC20,FZR1	0.9942	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons