DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
QRPGLIKIR
Uniprot ID:
Q5KSL6
Source protein:
Diacylglycerol kinase kappa
Source gene:
DGKK
Class:
DEG_APCC_DBOX_1
Location:
1017:1025
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5898
ASA_SCORE:
59.5222
COIL:
0.3687
CONS_SCORE:
0.3561
DSS_SCORE:
0.159
HELIX:
0.0136
FCONS_SCORE:
0.7877
RIG_SCORE:
0.8797
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Q1017K
SIDM00403
T-Lymphoblastic Leukemia
GDSC
QRPGLIKIR
DEG_APCC_DBOX_1
0.5833
p.Q1017E
SIDM00399
Head and Neck Carcinoma
GDSC
QRPGLIKIR
DEG_APCC_DBOX_1
0.5633
Drug responses associated with DGKK mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of QRPGLIKIR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5KSL6
Diacylglycerol kinase kappa
DEG_APCC_DBOX_1
1017:1025
QRPGLIKIR
APC,CDC20,FZR1
0.5898
More...