DegronMD

Uniprot ID: Q96L93

Source protein: Kinesin-like protein KIF16B

Source gene: KIF16B

Class: DEG_APCC_DBOX_1

Location: 1032:1040

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5293

ASA_SCORE: 104.9444

COIL: 0.3721

CONS_SCORE: 0.2385

DSS_SCORE: 0.5599

HELIX: 0.6246

FCONS_SCORE: 0.9632

RIG_SCORE: 0.6938

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1048V	TCGA-05-4427	LUAD	TCGA	QRQKLASLN	DEG_APCC_DBOX_1	0.1111
p.G1048V	DO23666	LUAD	ICGC	QRQKLASLN	DEG_APCC_DBOX_1	0.1111
p.M1027I	TCGA-24-2295	OV	TCGA	QRQKLASLN	DEG_APCC_DBOX_1	0.1944
p.M1027I	DO32173	OV	ICGC	QRQKLASLN	DEG_APCC_DBOX_1	0.1944
p.E1028D	TCGA-51-6867	LUSC	TCGA	QRQKLASLN	DEG_APCC_DBOX_1	0.2222
p.E1028D	DO26477	LUSC	ICGC	QRQKLASLN	DEG_APCC_DBOX_1	0.2222
p.S1041N	TCGA-68-7757	LUSC	TCGA	QRQKLASLN	DEG_APCC_DBOX_1	0.3056
p.S1041N	DO26886	LUSC	ICGC	QRQKLASLN	DEG_APCC_DBOX_1	0.3056
p.S1038N	TCGA-AP-A1DK	UCEC	TCGA	QRQKLASLN	DEG_APCC_DBOX_1	0.7069
p.S1038N	DO42033	UCEC	ICGC	QRQKLASLN	DEG_APCC_DBOX_1	0.7069
p.H1022Q	TCGA-CR-6474	HNSC	TCGA	QRQKLASLN	DEG_APCC_DBOX_1	0.0556
p.H1022Q	DO14542	HNSC	ICGC	QRQKLASLN	DEG_APCC_DBOX_1	0.0556
p.G1026D	TCGA-EO-A22R	UCEC	TCGA	QRQKLASLN	DEG_APCC_DBOX_1	0.1667
p.G1026D	DO42713	UCEC	ICGC	QRQKLASLN	DEG_APCC_DBOX_1	0.1667
p.G1042S	TCGA-UF-A7JA	HNSC	TCGA	QRQKLASLN	DEG_APCC_DBOX_1	0.2778
p.G1042S	DO52112	HNSC	ICGC	QRQKLASLN	DEG_APCC_DBOX_1	0.2778
p.S1047L	TCGA-VS-A8EB	CESC	TCGA	QRQKLASLN	DEG_APCC_DBOX_1	0.5833
p.S1047L	DO51617	CESC	ICGC	QRQKLASLN	DEG_APCC_DBOX_1	0.5833
p.M1027T	DO229010	COCA	ICGC	QRQKLASLN	DEG_APCC_DBOX_1	0.1944
p.M1027T	DO229013	COCA	ICGC	QRQKLASLN	DEG_APCC_DBOX_1	0.1944
p.M1027T	DO229016	COCA	ICGC	QRQKLASLN	DEG_APCC_DBOX_1	0.1944
p.M1027T	DO229003	COCA	ICGC	QRQKLASLN	DEG_APCC_DBOX_1	0.1944
p.M1027T	DO229005	COCA	ICGC	QRQKLASLN	DEG_APCC_DBOX_1	0.1944
p.M1027T	DO35192	PACA	ICGC	QRQKLASLN	DEG_APCC_DBOX_1	0.1944
p.A1037D	DO229031	LICA	ICGC	QRQKLASLN	DEG_APCC_DBOX_1	0.6682
p.A1037D	DO229035	LICA	ICGC	QRQKLASLN	DEG_APCC_DBOX_1	0.6682
p.H1022R	SIDM00454	Rhabdomyosarcoma	GDSC	QRQKLASLN	DEG_APCC_DBOX_1	0.0556
p.H1022R	SIDM00309	Mesothelioma	GDSC	QRQKLASLN	DEG_APCC_DBOX_1	0.0556
p.H1022R	SIDM01664	Prostate Carcinoma	GDSC	QRQKLASLN	DEG_APCC_DBOX_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QRQKLASLN

Degron related mutations and impact score

Drug responses associated with KIF16B mutations

All proteins holding degron of QRQKLASLN

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96L93	Kinesin-like protein KIF16B	DEG_APCC_DBOX_1	1032:1040	QRQKLASLN	APC,CDC20,FZR1	0.5293	More...