DegronMD

Uniprot ID: Q13884

Source protein: Beta-1-syntrophin

Source gene: SNTB1

Class: DEG_APCC_DBOX_1

Location: 21:29

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7705

ASA_SCORE: 48.9778

COIL: 0.2217

CONS_SCORE: 0.5366

DSS_SCORE: 0.2254

HELIX: 0.1134

FCONS_SCORE: 1.2611

RIG_SCORE: 0.7967

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R31L	TCGA-BF-A1Q0	SKCM	TCGA	QRSGLLEVL	DEG_APCC_DBOX_1	0.2778
p.R31L	TCGA-CQ-5326	HNSC	TCGA	QRSGLLEVL	DEG_APCC_DBOX_1	0.2778
p.R31L	TCGA-CX-7219	HNSC	TCGA	QRSGLLEVL	DEG_APCC_DBOX_1	0.2778
p.R31L	TCGA-D3-A2JG	SKCM	TCGA	QRSGLLEVL	DEG_APCC_DBOX_1	0.2778
p.R31L	TCGA-ER-A19H	SKCM	TCGA	QRSGLLEVL	DEG_APCC_DBOX_1	0.2778
p.R31L	DO14910	HNSC	ICGC	QRSGLLEVL	DEG_APCC_DBOX_1	0.2778
p.R31L	DO15286	HNSC	ICGC	QRSGLLEVL	DEG_APCC_DBOX_1	0.2778
p.R31L	DO47299	SKCM	ICGC	QRSGLLEVL	DEG_APCC_DBOX_1	0.2778
p.R31L	DO47374	SKCM	ICGC	QRSGLLEVL	DEG_APCC_DBOX_1	0.2778
p.R31L	DO47613	SKCM	ICGC	QRSGLLEVL	DEG_APCC_DBOX_1	0.2778
p.G24W	TCGA-D3-A1Q1	SKCM	TCGA	QRSGLLEVL	DEG_APCC_DBOX_1	0.6714
p.G24W	TCGA-DA-A1I5	SKCM	TCGA	QRSGLLEVL	DEG_APCC_DBOX_1	0.6714
p.G24W	DO37447	SKCM	ICGC	QRSGLLEVL	DEG_APCC_DBOX_1	0.6714
p.G24W	DO37445	SKCM	ICGC	QRSGLLEVL	DEG_APCC_DBOX_1	0.6714
p.V37G	TCGA-FF-8042	DLBC	TCGA	QRSGLLEVL	DEG_APCC_DBOX_1	0.1111
p.V37G	DO222306	DLBC	ICGC	QRSGLLEVL	DEG_APCC_DBOX_1	0.1111
p.D32Y	DO218553	BRCA	ICGC	QRSGLLEVL	DEG_APCC_DBOX_1	0.25
p.G24R	DO50332	ESAD	ICGC	QRSGLLEVL	DEG_APCC_DBOX_1	0.6457
p.R19L	DO229259	THCA	ICGC	QRSGLLEVL	DEG_APCC_DBOX_1	0.2778
p.D32N	DO229544	UTCA	ICGC	QRSGLLEVL	DEG_APCC_DBOX_1	0.25
p.L25M	SIDM00915	Small Cell Lung Carcinoma	GDSC	QRSGLLEVL	DEG_APCC_DBOX_1	0.711
p.R19Q	SIDM00600	Thyroid Gland Carcinoma	GDSC	QRSGLLEVL	DEG_APCC_DBOX_1	0.2778
p.R19Q	SIDM01144	Gastric Carcinoma	GDSC	QRSGLLEVL	DEG_APCC_DBOX_1	0.2778
p.R19Q	SIDM00592	Oral Cavity Carcinoma	GDSC	QRSGLLEVL	DEG_APCC_DBOX_1	0.2778
p.R19Q	SIDM00533	Pancreatic Carcinoma	GDSC	QRSGLLEVL	DEG_APCC_DBOX_1	0.2778
p.R19Q	SIDM00466	Ovarian Carcinoma	GDSC	QRSGLLEVL	DEG_APCC_DBOX_1	0.2778
p.R19Q	SIDM01093	Cervical Carcinoma	GDSC	QRSGLLEVL	DEG_APCC_DBOX_1	0.2778
p.R19Q	SIDM00556	Neuroblastoma	GDSC	QRSGLLEVL	DEG_APCC_DBOX_1	0.2778
p.R19Q	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	QRSGLLEVL	DEG_APCC_DBOX_1	0.2778
p.R19Q	SIDM00077	Oral Cavity Carcinoma	GDSC	QRSGLLEVL	DEG_APCC_DBOX_1	0.2778
p.R19Q	SIDM00575	Glioma	GDSC	QRSGLLEVL	DEG_APCC_DBOX_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: QRSGLLEVL

Degron related mutations and impact score

Drug responses associated with SNTB1 mutations

All proteins holding degron of QRSGLLEVL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13884	Beta-1-syntrophin	DEG_APCC_DBOX_1	21:29	QRSGLLEVL	APC,CDC20,FZR1	0.7705	More...