DegronMD

Uniprot ID: Q9BW19

Source protein: Kinesin-like protein KIFC1

Source gene: KIFC1

Class: DEG_APCC_DBOX_1

Location: 4:12

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7075

ASA_SCORE: 91.7667

COIL: 0.582

CONS_SCORE: 0.2258

DSS_SCORE: 0.6563

HELIX: 0.3393

FCONS_SCORE: 1.0238

RIG_SCORE: 0.7302

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S6F	TCGA-EE-A2GI	SKCM	TCGA	QRSPLLEVK	DEG_APCC_DBOX_1	0.7982
p.S6F	DO37410	SKCM	ICGC	QRSPLLEVK	DEG_APCC_DBOX_1	0.7982
p.P3L	TCGA-FR-A728	SKCM	TCGA	QRSPLLEVK	DEG_APCC_DBOX_1	0.75
p.P3L	DO48550	SKCM	ICGC	QRSPLLEVK	DEG_APCC_DBOX_1	0.75
p.D2N	SIDM01617	Endometrial Carcinoma	GDSC	QRSPLLEVK	DEG_APCC_DBOX_1	0.7222
p.D2N	ACH-000994	Endometrial/Uterine Cancer	CCLE	QRSPLLEVK	DEG_APCC_DBOX_1	0.7222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BW19	Kinesin-like protein KIFC1	DEG_APCC_DBOX_1	4:12	QRSPLLEVK	APC,CDC20,FZR1	0.7075	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons