DegronMD - Q9BW19(KIFC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q77H	TCGA-A5-A0G2	UCEC	TCGA	TTSHPRVPSL	DEG_COP1_1	63:72	Mutation rewiring degron network	0.1944
p.Q77H	DO41235	UCEC	ICGC	TTSHPRVPSL	DEG_COP1_1	63:72	Mutation rewiring degron network	0.1944
p.A58T	TCGA-AX-A1CE	UCEC	TCGA	TTSHPRVPSL	DEG_COP1_1	63:72	Mutation rewiring degron network	0.1944
p.A58T	DO42280	UCEC	ICGC	TTSHPRVPSL	DEG_COP1_1	63:72	Mutation rewiring degron network	0.1944
p.G57S	TCGA-B5-A1MX	UCEC	TCGA	TTSHPRVPSL	DEG_COP1_1	63:72	Mutation rewiring degron network	0.1667
p.G57S	DO41999	UCEC	ICGC	TTSHPRVPSL	DEG_COP1_1	63:72	Mutation rewiring degron network	0.1667
p.P70A	TCGA-CG-4469	STAD	TCGA	TTSHPRVPSL	DEG_COP1_1	63:72	Mutation altering degron motif	0.7503
p.P70A	DO38507	STAD	ICGC	TTSHPRVPSL	DEG_COP1_1	63:72	Mutation altering degron motif	0.7503
p.L72I	TCGA-D3-A2JP	SKCM	TCGA	TTSHPRVPSL	DEG_COP1_1	63:72	Mutation altering degron motif	0.6063
p.L72I	DO47407	SKCM	ICGC	TTSHPRVPSL	DEG_COP1_1	63:72	Mutation altering degron motif	0.6063
p.S6F	TCGA-EE-A2GI	SKCM	TCGA	QRSPLLEVK	DEG_APCC_DBOX_1	4:12	Mutation altering degron motif	0.7982
p.S6F	DO37410	SKCM	ICGC	QRSPLLEVK	DEG_APCC_DBOX_1	4:12	Mutation altering degron motif	0.7982
p.P3L	TCGA-FR-A728	SKCM	TCGA	QRSPLLEVK	DEG_APCC_DBOX_1	4:12	Mutation blocking ubiquitination signal	0.75
p.P3L	DO48550	SKCM	ICGC	QRSPLLEVK	DEG_APCC_DBOX_1	4:12	Mutation blocking ubiquitination signal	0.75
p.R54T	TCGA-ZF-AA54	BLCA	TCGA	TTSHPRVPSL	DEG_COP1_1	63:72	Mutation rewiring degron network	0.0833
p.R54T	DO219098	BLCA	ICGC	TTSHPRVPSL	DEG_COP1_1	63:72	Mutation rewiring degron network	0.0833
p.T59M	DO222864	COCA	ICGC	TTSHPRVPSL	DEG_COP1_1	63:72	Mutation rewiring degron network	0.2222
p.V69I	SIDM01229	Neuroblastoma	GDSC	TTSHPRVPSL	DEG_COP1_1	63:72	Mutation altering degron motif	0.7076
p.V69I	ACH-002217	Neuroblastoma	CCLE	TTSHPRVPSL	DEG_COP1_1	63:72	Mutation altering degron motif	0.7076
p.V69I	BE2-M17	autonomic ganglia	COSMIC	TTSHPRVPSL	DEG_COP1_1	63:72	Mutation altering degron motif	0.7076
p.D2N	SIDM01617	Endometrial Carcinoma	GDSC	QRSPLLEVK	DEG_APCC_DBOX_1	4:12	Mutation blocking ubiquitination signal	0.7222
p.D2N	ACH-000994	Endometrial/Uterine Cancer	CCLE	QRSPLLEVK	DEG_APCC_DBOX_1	4:12	Mutation blocking ubiquitination signal	0.7222
p.S71F	ACH-001061	Colon/Colorectal Cancer	CCLE	TTSHPRVPSL	DEG_COP1_1	63:72	Mutation altering degron motif	0.9093

Kaplan plot for KIFC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIFC1

UniProt ID: Q9BW19

Entrez ID: 3833

Protein name: Kinesin-like protein KIFC1 (Kinesin-like protein 2) (Kinesin-related protein HSET)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIFC1 in