DegronMD

Uniprot ID: Q9BW19

Source protein: Kinesin-like protein KIFC1

Source gene: KIFC1

Class: DEG_COP1_1

Location: 63:72

E3 ligase: COP1

DEGRON score: 0.9262

ASA_SCORE: 97.12

COIL: 0.9499

CONS_SCORE: 0.2174

DSS_SCORE: 0.6839

HELIX: 0.024

FCONS_SCORE: 0.9058

RIG_SCORE: 0.6879

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q77H	TCGA-A5-A0G2	UCEC	TCGA	TTSHPRVPSL	DEG_COP1_1	0.1944
p.Q77H	DO41235	UCEC	ICGC	TTSHPRVPSL	DEG_COP1_1	0.1944
p.A58T	TCGA-AX-A1CE	UCEC	TCGA	TTSHPRVPSL	DEG_COP1_1	0.1944
p.A58T	DO42280	UCEC	ICGC	TTSHPRVPSL	DEG_COP1_1	0.1944
p.G57S	TCGA-B5-A1MX	UCEC	TCGA	TTSHPRVPSL	DEG_COP1_1	0.1667
p.G57S	DO41999	UCEC	ICGC	TTSHPRVPSL	DEG_COP1_1	0.1667
p.P70A	TCGA-CG-4469	STAD	TCGA	TTSHPRVPSL	DEG_COP1_1	0.7503
p.P70A	DO38507	STAD	ICGC	TTSHPRVPSL	DEG_COP1_1	0.7503
p.L72I	TCGA-D3-A2JP	SKCM	TCGA	TTSHPRVPSL	DEG_COP1_1	0.6063
p.L72I	DO47407	SKCM	ICGC	TTSHPRVPSL	DEG_COP1_1	0.6063
p.R54T	TCGA-ZF-AA54	BLCA	TCGA	TTSHPRVPSL	DEG_COP1_1	0.0833
p.R54T	DO219098	BLCA	ICGC	TTSHPRVPSL	DEG_COP1_1	0.0833
p.T59M	DO222864	COCA	ICGC	TTSHPRVPSL	DEG_COP1_1	0.2222
p.V69I	SIDM01229	Neuroblastoma	GDSC	TTSHPRVPSL	DEG_COP1_1	0.7076
p.V69I	ACH-002217	Neuroblastoma	CCLE	TTSHPRVPSL	DEG_COP1_1	0.7076
p.V69I	BE2-M17	autonomic_ganglia	COSMIC	TTSHPRVPSL	DEG_COP1_1	0.7076
p.S71F	ACH-001061	Colon/Colorectal Cancer	CCLE	TTSHPRVPSL	DEG_COP1_1	0.9093

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BW19	Kinesin-like protein KIFC1	DEG_COP1_1	63:72	TTSHPRVPSL	COP1	0.9262	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons