DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
QRTVLPKLV
Uniprot ID:
Q92630
Source protein:
Dual specificity tyrosine-phosphorylation-regulated kinase 2
Source gene:
DYRK2
Class:
DEG_APCC_DBOX_1
Location:
592:600
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8714
ASA_SCORE:
113.8
COIL:
0.8177
CONS_SCORE:
0.4974
DSS_SCORE:
0.7111
HELIX:
0.0311
FCONS_SCORE:
1.1396
RIG_SCORE:
0.8076
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with DYRK2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of QRTVLPKLV
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q92630
Dual specificity tyrosine-phosphorylation-regulated kinase 2
DEG_APCC_DBOX_1
592:600
QRTVLPKLV
APC,CDC20,FZR1
0.8714
More...