DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
QWENTPLK
Uniprot ID:
Q9UKL3
Source protein:
CASP8-associated protein 2
Source gene:
CASP8AP2
Class:
DEG_SCF_SKP2-CKS1_1
Location:
456:463
E3 ligase:
SKP2,CSK1
DEGRON score:
0.8413
ASA_SCORE:
126.9625
COIL:
0.753
CONS_SCORE:
0.5002
DSS_SCORE:
0.6278
HELIX:
0.2241
FCONS_SCORE:
0.8717
RIG_SCORE:
0.6919
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CASP8AP2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of QWENTPLK
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9UKL3
CASP8-associated protein 2
DEG_SCF_SKP2-CKS1_1
456:463
QWENTPLK
SKP2,CSK1
0.8413
More...