DegronMD

Uniprot ID: Q9HCM2

Source protein: Plexin-A4

Source gene: PLXNA4

Class: LIG_APCC_ABBAyCdc20_2

Location: 1025:1031

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5123

ASA_SCORE: 81.3857

COIL: 0.4844

CONS_SCORE: 0.3919

DSS_SCORE: 0.1144

HELIX: 0.0084

FCONS_SCORE: 0.7418

RIG_SCORE: 0.8713

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1028M	TCGA-05-4398	LUAD	TCGA	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.6507
p.I1028M	TCGA-CX-7086	HNSC	TCGA	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.6507
p.I1028M	DO15046	HNSC	ICGC	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.6507
p.I1028M	DO25847	LUAD	ICGC	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.6507
p.D1031V	TCGA-29-1781	OV	TCGA	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.7785
p.D1031V	DO29578	OV	ICGC	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.7785
p.A1026V	TCGA-AD-6964	COAD	TCGA	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.5825
p.A1026V	DO8360	COAD	ICGC	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.5825
p.A1026V	DO229177	LMS	ICGC	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.5825
p.D1039A	TCGA-AZ-4315	COAD	TCGA	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.1111
p.D1039A	DO8842	COAD	ICGC	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.1111
p.D1031Y	TCGA-B5-A1MR	UCEC	TCGA	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.7325
p.D1031Y	DO41758	UCEC	ICGC	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.7325
p.R1025K	TCGA-D3-A8GM	SKCM	TCGA	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.6126
p.R1025K	DO50288	SKCM	ICGC	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.6126
p.E1016G	TCGA-D9-A6EC	SKCM	TCGA	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.0833
p.E1016G	DO50291	SKCM	ICGC	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R1025S	TCGA-DK-A6AV	BLCA	TCGA	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.7427
p.R1025S	DO48575	BLCA	ICGC	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.7427
p.D1039N	TCGA-FS-A1ZZ	SKCM	TCGA	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.1111
p.D1039N	DO37412	SKCM	ICGC	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.1111
p.V1037M	TCGA-JY-A6FB	ESCA	TCGA	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.1667
p.K1027M	TCGA-VQ-A91S	STAD	TCGA	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.6951
p.K1027M	DO222352	STAD	ICGC	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.6951
p.S1020P	DO229227	THCA	ICGC	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.1944
p.M1017I	SIDM00791	Chronic Myelogenous Leukemia	GDSC	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.1111
p.M1017I	ACH-000068	Lymphoma	CCLE	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.1111
p.M1017I	ACH-000551	Leukemia	CCLE	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.1111
p.M1017I	ACH-002061	Leukemia	CCLE	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.1111
p.M1017I	K-562	haematopoietic_and_lymphoid_tissue	COSMIC	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.1111
p.S1020L	SIDM00633	Breast Carcinoma	GDSC	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.1944
p.S1020L	ACH-000759	Breast Cancer	CCLE	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.1944
p.S1020L	MDA-MB-175-VII	breast	COSMIC	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.1944
p.Q1022R	SIDM00465	Ovarian Carcinoma	GDSC	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.25
p.Q1022R	ACH-002183	Ovarian Cancer	CCLE	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.25
p.Q1022R	OVMIU	ovary	COSMIC	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.25
p.H1029Y	SIDM00140	Melanoma	GDSC	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.6118
p.H1029Y	ACH-000968	Skin Cancer	CCLE	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.6118
p.H1029Y	COLO-792	skin	COSMIC	RAKIHQD	LIG_APCC_ABBAyCdc20_2	0.6118

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RAKIHQD

Degron related mutations and impact score

Drug responses associated with PLXNA4 mutations

All proteins holding degron of RAKIHQD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HCM2	Plexin-A4	LIG_APCC_ABBAyCdc20_2	1025:1031	RAKIHQD	APC,CDC20,FZR1	0.5123	More...