DegronMD

Uniprot ID: Q02817

Source protein: Mucin-2

Source gene: MUC2

Class: LIG_APCC_ABBAyCdc20_2

Location: 1824:1830

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6859

ASA_SCORE: 76.4571

COIL: 0.7103

CONS_SCORE: 0.2642

DSS_SCORE: 0.1535

HELIX: 0.0181

FCONS_SCORE: 0.9079

RIG_SCORE: 0.8654

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1832G	TCGA-56-8628	LUSC	TCGA	RATMYPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.S1832G	DO45433	LUSC	ICGC	RATMYPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.T1818A	TCGA-96-A4JK	LUSC	TCGA	RATMYPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.T1818A	DO45442	LUSC	ICGC	RATMYPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.S1832N	TCGA-A5-A0G2	UCEC	TCGA	RATMYPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.S1832N	DO41235	UCEC	ICGC	RATMYPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.T1837P	TCGA-AA-3715	COAD	TCGA	RATMYPD	LIG_APCC_ABBAyCdc20_2	0.1389
p.T1837P	DO8018	COAD	ICGC	RATMYPD	LIG_APCC_ABBAyCdc20_2	0.1389
p.T1821A	TCGA-D8-A1J8	BRCA	TCGA	RATMYPD	LIG_APCC_ABBAyCdc20_2	0.25
p.T1821A	DO1269	BRCA	ICGC	RATMYPD	LIG_APCC_ABBAyCdc20_2	0.25
p.H1838Y	TCGA-GN-A266	SKCM	TCGA	RATMYPD	LIG_APCC_ABBAyCdc20_2	0.1111
p.H1838Y	DO37432	SKCM	ICGC	RATMYPD	LIG_APCC_ABBAyCdc20_2	0.1111
p.P1836L	TCGA-Z6-A9VB	ESCA	TCGA	RATMYPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.S1817T	DO229061	LICA	ICGC	RATMYPD	LIG_APCC_ABBAyCdc20_2	0.1389
p.S1817T	DO229140	THCA	ICGC	RATMYPD	LIG_APCC_ABBAyCdc20_2	0.1389
p.S1817T	DO229088	THCA	ICGC	RATMYPD	LIG_APCC_ABBAyCdc20_2	0.1389
p.S1817T	DO231475	THCA	ICGC	RATMYPD	LIG_APCC_ABBAyCdc20_2	0.1389
p.P1835L	DO222402	MELA	ICGC	RATMYPD	LIG_APCC_ABBAyCdc20_2	0.1944
p.S1817R	ACH-000204	Myeloma	CCLE	RATMYPD	LIG_APCC_ABBAyCdc20_2	0.1389
p.I1816F	ACH-000464	Brain Cancer	CCLE	RATMYPD	LIG_APCC_ABBAyCdc20_2	0.1111
p.G1834W	ACH-000734	Liver Cancer	CCLE	RATMYPD	LIG_APCC_ABBAyCdc20_2	0.2222
p.I1816M	ACH-000778	Head and Neck Cancer	CCLE	RATMYPD	LIG_APCC_ABBAyCdc20_2	0.1111
p.P1826L	ACH-001521	Skin Cancer	CCLE	RATMYPD	LIG_APCC_ABBAyCdc20_2	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02817	Mucin-2	LIG_APCC_ABBAyCdc20_2	1824:1830	RATMYPD	APC,CDC20,FZR1	0.6859	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons