DegronMD

Uniprot ID: P0CW27

Source protein: Coiled-coil domain-containing protein 166

Source gene: CCDC166

Class: LIG_APCC_ABBAyCdc20_2

Location: 252:258

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7715

ASA_SCORE: 116.0571

COIL: 0.1836

CONS_SCORE: 0.5257

DSS_SCORE: 0.4341

HELIX: 0.8189

FCONS_SCORE: 1.2484

RIG_SCORE: 0.7053

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R246C	DO229016	COCA	ICGC	REQLHRE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R252C	DO233888	GACA	ICGC	REQLHRE	LIG_APCC_ABBAyCdc20_2	0.8301
p.R252C	ACH-000982	Colon/Colorectal Cancer	CCLE	REQLHRE	LIG_APCC_ABBAyCdc20_2	0.8301
p.E250K	DO222727	MELA	ICGC	REQLHRE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R245Q	DO38404	STAD	ICGC	REQLHRE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R246H	DO38671	STAD	ICGC	REQLHRE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R267H	DO38655	STAD	ICGC	REQLHRE	LIG_APCC_ABBAyCdc20_2	0.0833
p.E250G	DO229259	THCA	ICGC	REQLHRE	LIG_APCC_ABBAyCdc20_2	0.2778
p.T262M	ACH-000969	Colon/Colorectal Cancer	CCLE	REQLHRE	LIG_APCC_ABBAyCdc20_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P0CW27	Coiled-coil domain-containing protein 166	LIG_APCC_ABBAyCdc20_2	252:258	REQLHRE	APC,CDC20,FZR1	0.7715	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons