DegronMD - P0CW27(CCDC166)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R119C	TCGA-EO-A3B0	UCEC	TCGA	VRAQLLEME	DEG_APCC_DBOX_1	123:131	Mutation rewiring degron network	0.2222
p.R119C	DO233082	GACA	ICGC	VRAQLLEME	DEG_APCC_DBOX_1	123:131	Mutation rewiring degron network	0.2222
p.R119C	DO233634	GACA	ICGC	VRAQLLEME	DEG_APCC_DBOX_1	123:131	Mutation rewiring degron network	0.2222
p.R119C	DO219773	UCEC	ICGC	VRAQLLEME	DEG_APCC_DBOX_1	123:131	Mutation rewiring degron network	0.2222
p.R133H	TCGA-L5-A8NM	ESCA	TCGA	VRAQLLEME	DEG_APCC_DBOX_1	123:131	Mutation rewiring degron network	0.2778
p.R133H	DO233119	GACA	ICGC	VRAQLLEME	DEG_APCC_DBOX_1	123:131	Mutation rewiring degron network	0.2778
p.Y116D	TCGA-UB-A7MB	LIHC	TCGA	VRAQLLEME	DEG_APCC_DBOX_1	123:131	Mutation rewiring degron network	0.1389
p.Y116D	DO52318	LIHC	ICGC	VRAQLLEME	DEG_APCC_DBOX_1	123:131	Mutation rewiring degron network	0.1389
p.A134V	DO222973	BTCA	ICGC	VRAQLLEME	DEG_APCC_DBOX_1	123:131	Mutation rewiring degron network	0.25
p.R246C	DO229016	COCA	ICGC	REQLHRE	LIG_APCC_ABBAyCdc20_2	252:258	Mutation rewiring degron network	0.1667
p.A134E	DO228114	EOPC	ICGC	VRAQLLEME	DEG_APCC_DBOX_1	123:131	Mutation rewiring degron network	0.25
p.S114L	DO234391	ESAD	ICGC	VRAQLLEME	DEG_APCC_DBOX_1	123:131	Mutation rewiring degron network	0.0833
p.G355V	DO233259	GACA	ICGC	SSMDSRVPSL	DEG_COP1_1	340:349	Mutation rewiring degron network	0.1667
p.L349M	DO233780	GACA	ICGC	SSMDSRVPSL	DEG_COP1_1	340:349	Mutation altering degron motif	0.5999
p.R124H	DO233791	GACA	ICGC	VRAQLLEME	DEG_APCC_DBOX_1	123:131	Mutation altering degron motif	0.8244
p.R124H	DO38380	STAD	ICGC	VRAQLLEME	DEG_APCC_DBOX_1	123:131	Mutation altering degron motif	0.8244
p.R252C	DO233888	GACA	ICGC	REQLHRE	LIG_APCC_ABBAyCdc20_2	252:258	Mutation altering degron motif	0.8301
p.R252C	ACH-000982	Colon/Colorectal Cancer	CCLE	REQLHRE	LIG_APCC_ABBAyCdc20_2	252:258	Mutation altering degron motif	0.8301
p.A318T	DO233855	GACA	ICGC	SREASRVPSL	DEG_COP1_1	328:337	Mutation rewiring degron network	0.0556
p.V326F	DO23278	LINC	ICGC	SREASRVPSL	DEG_COP1_1	328:337	Mutation rewiring degron network	0.2778
p.A125T	DO45299	LIRI	ICGC	VRAQLLEME	DEG_APCC_DBOX_1	123:131	Mutation altering degron motif	0.6028
p.E250K	DO222727	MELA	ICGC	REQLHRE	LIG_APCC_ABBAyCdc20_2	252:258	Mutation rewiring degron network	0.2778
p.G118R	DO33624	PACA	ICGC	VRAQLLEME	DEG_APCC_DBOX_1	123:131	Mutation rewiring degron network	0.1944
p.R245Q	DO38404	STAD	ICGC	REQLHRE	LIG_APCC_ABBAyCdc20_2	252:258	Mutation rewiring degron network	0.1389
p.R246H	DO38671	STAD	ICGC	REQLHRE	LIG_APCC_ABBAyCdc20_2	252:258	Mutation rewiring degron network	0.1667
p.R267H	DO38655	STAD	ICGC	REQLHRE	LIG_APCC_ABBAyCdc20_2	252:258	Mutation rewiring degron network	0.0833
p.E250G	DO229259	THCA	ICGC	REQLHRE	LIG_APCC_ABBAyCdc20_2	252:258	Mutation rewiring degron network	0.2778
p.R345G	DO229087	THCA	ICGC	SSMDSRVPSL	DEG_COP1_1	340:349	Mutation altering degron motif	0.6457
p.R329H	ACH-000788	Skin Cancer	CCLE	SREASRVPSL	DEG_COP1_1	328:337	Mutation altering degron motif	0.7133
p.R345K	ACH-000911	Gastric Cancer	CCLE	SSMDSRVPSL	DEG_COP1_1	340:349	Mutation altering degron motif	0.6126
p.T262M	ACH-000969	Colon/Colorectal Cancer	CCLE	REQLHRE	LIG_APCC_ABBAyCdc20_2	252:258	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC166

UniProt ID: P0CW27

Entrez ID: 100130274

Protein name: Coiled-coil domain-containing protein 166

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC166 in