DegronMD

Uniprot ID: P0CW27

Source protein: Coiled-coil domain-containing protein 166

Source gene: CCDC166

Class: DEG_COP1_1

Location: 328:337

E3 ligase: COP1

DEGRON score: 0.9548

ASA_SCORE: 86.74

COIL: 0.8946

CONS_SCORE: 0.2648

DSS_SCORE: 0.4232

HELIX: 0.0427

FCONS_SCORE: 1.1011

RIG_SCORE: 0.6891

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A318T	DO233855	GACA	ICGC	SREASRVPSL	DEG_COP1_1	0.0556
p.V326F	DO23278	LINC	ICGC	SREASRVPSL	DEG_COP1_1	0.2778
p.R329H	ACH-000788	Skin Cancer	CCLE	SREASRVPSL	DEG_COP1_1	0.7133

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P0CW27	Coiled-coil domain-containing protein 166	DEG_COP1_1	328:337	SREASRVPSL	COP1	0.9548	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons