DegronMD

Uniprot ID: P0CW27

Source protein: Coiled-coil domain-containing protein 166

Source gene: CCDC166

Class: DEG_COP1_1

Location: 340:349

E3 ligase: COP1

DEGRON score: 0.9706

ASA_SCORE: 82.34

COIL: 0.9022

CONS_SCORE: 0.2362

DSS_SCORE: 0.4037

HELIX: 0.0485

FCONS_SCORE: 0.8597

RIG_SCORE: 0.6937

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G355V	DO233259	GACA	ICGC	SSMDSRVPSL	DEG_COP1_1	0.1667
p.L349M	DO233780	GACA	ICGC	SSMDSRVPSL	DEG_COP1_1	0.5999
p.R345G	DO229087	THCA	ICGC	SSMDSRVPSL	DEG_COP1_1	0.6457
p.R345K	ACH-000911	Gastric Cancer	CCLE	SSMDSRVPSL	DEG_COP1_1	0.6126

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P0CW27	Coiled-coil domain-containing protein 166	DEG_COP1_1	340:349	SSMDSRVPSL	COP1	0.9706	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons