DegronMD

Uniprot ID: P0CW27

Source protein: Coiled-coil domain-containing protein 166

Source gene: CCDC166

Class: DEG_APCC_DBOX_1

Location: 123:131

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6039

ASA_SCORE: 85.8556

COIL: 0.0106

CONS_SCORE: 0.3539

DSS_SCORE: 0.2729

HELIX: 0.9896

FCONS_SCORE: 1.1853

RIG_SCORE: 0.8042

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R119C	TCGA-EO-A3B0	UCEC	TCGA	VRAQLLEME	DEG_APCC_DBOX_1	0.2222
p.R119C	DO233082	GACA	ICGC	VRAQLLEME	DEG_APCC_DBOX_1	0.2222
p.R119C	DO233634	GACA	ICGC	VRAQLLEME	DEG_APCC_DBOX_1	0.2222
p.R119C	DO219773	UCEC	ICGC	VRAQLLEME	DEG_APCC_DBOX_1	0.2222
p.R133H	TCGA-L5-A8NM	ESCA	TCGA	VRAQLLEME	DEG_APCC_DBOX_1	0.2778
p.R133H	DO233119	GACA	ICGC	VRAQLLEME	DEG_APCC_DBOX_1	0.2778
p.Y116D	TCGA-UB-A7MB	LIHC	TCGA	VRAQLLEME	DEG_APCC_DBOX_1	0.1389
p.Y116D	DO52318	LIHC	ICGC	VRAQLLEME	DEG_APCC_DBOX_1	0.1389
p.A134V	DO222973	BTCA	ICGC	VRAQLLEME	DEG_APCC_DBOX_1	0.25
p.A134E	DO228114	EOPC	ICGC	VRAQLLEME	DEG_APCC_DBOX_1	0.25
p.S114L	DO234391	ESAD	ICGC	VRAQLLEME	DEG_APCC_DBOX_1	0.0833
p.R124H	DO233791	GACA	ICGC	VRAQLLEME	DEG_APCC_DBOX_1	0.8244
p.R124H	DO38380	STAD	ICGC	VRAQLLEME	DEG_APCC_DBOX_1	0.8244
p.A125T	DO45299	LIRI	ICGC	VRAQLLEME	DEG_APCC_DBOX_1	0.6028
p.G118R	DO33624	PACA	ICGC	VRAQLLEME	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P0CW27	Coiled-coil domain-containing protein 166	DEG_APCC_DBOX_1	123:131	VRAQLLEME	APC,CDC20,FZR1	0.6039	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons