DegronMD

Uniprot ID: O00625

Source protein: Pirin

Source gene: PIR

Class: LIG_APCC_ABBAyCdc20_2

Location: 97:103

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6746

ASA_SCORE: 19.7

COIL: 0.2671

CONS_SCORE: 0.7474

DSS_SCORE: 0.3996

HELIX: 0.0287

FCONS_SCORE: 1.3001

RIG_SCORE: 0.7643

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H112D	TCGA-A8-A09W	BRCA	TCGA	RGILHAE	LIG_APCC_ABBAyCdc20_2	0.0833
p.H112D	DO1476	BRCA	ICGC	RGILHAE	LIG_APCC_ABBAyCdc20_2	0.0833
p.A95V	TCGA-BR-8680	STAD	TCGA	RGILHAE	LIG_APCC_ABBAyCdc20_2	0.2778
p.A95V	DO52674	MALY	ICGC	RGILHAE	LIG_APCC_ABBAyCdc20_2	0.2778
p.A95V	DO47769	STAD	ICGC	RGILHAE	LIG_APCC_ABBAyCdc20_2	0.2778
p.A95V	ACH-001369	Ovarian Cancer	CCLE	RGILHAE	LIG_APCC_ABBAyCdc20_2	0.2778
p.P105T	TCGA-BS-A0TI	UCEC	TCGA	RGILHAE	LIG_APCC_ABBAyCdc20_2	0.2778
p.P105T	DO41608	UCEC	ICGC	RGILHAE	LIG_APCC_ABBAyCdc20_2	0.2778
p.M104V	TCGA-EO-A22U	UCEC	TCGA	RGILHAE	LIG_APCC_ABBAyCdc20_2	0.3056
p.M104V	DO43755	UCEC	ICGC	RGILHAE	LIG_APCC_ABBAyCdc20_2	0.3056
p.C106F	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	RGILHAE	LIG_APCC_ABBAyCdc20_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00625	Pirin	LIG_APCC_ABBAyCdc20_2	97:103	RGILHAE	APC,CDC20,FZR1	0.6746	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons