DegronMD

Uniprot ID: O14815

Source protein: Calpain-9

Source gene: CAPN9

Class: LIG_APCC_ABBAyCdc20_2

Location: 39:45

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9846

ASA_SCORE: 59.4714

COIL: 0.7461

CONS_SCORE: 0.662

DSS_SCORE: 0.4256

HELIX: 0.0821

FCONS_SCORE: 1.0798

RIG_SCORE: 0.7807

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E30Q	TCGA-05-4397	LUAD	TCGA	RGTLFED	LIG_APCC_ABBAyCdc20_2	0.0833
p.E30Q	DO25320	LUAD	ICGC	RGTLFED	LIG_APCC_ABBAyCdc20_2	0.0833
p.S51N	TCGA-BG-A222	UCEC	TCGA	RGTLFED	LIG_APCC_ABBAyCdc20_2	0.1667
p.S51N	DO42977	UCEC	ICGC	RGTLFED	LIG_APCC_ABBAyCdc20_2	0.1667
p.L37R	TCGA-L5-A8NG	ESCA	TCGA	RGTLFED	LIG_APCC_ABBAyCdc20_2	0.2778
p.A46S	DO229019	LICA	ICGC	RGTLFED	LIG_APCC_ABBAyCdc20_2	0.3056
p.E30D	DO229015	LICA	ICGC	RGTLFED	LIG_APCC_ABBAyCdc20_2	0.0833
p.F48S	ACH-000008	Skin Cancer	CCLE	RGTLFED	LIG_APCC_ABBAyCdc20_2	0.25
p.F48S	ACH-000202	Colon/Colorectal Cancer	CCLE	RGTLFED	LIG_APCC_ABBAyCdc20_2	0.25
p.F48S	ACH-001024	Skin Cancer	CCLE	RGTLFED	LIG_APCC_ABBAyCdc20_2	0.25
p.F48S	ACH-002120	Skin Cancer	CCLE	RGTLFED	LIG_APCC_ABBAyCdc20_2	0.25
p.G40V	ACH-001863	Bile Duct Cancer	CCLE	RGTLFED	LIG_APCC_ABBAyCdc20_2	0.6421

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14815	Calpain-9	LIG_APCC_ABBAyCdc20_2	39:45	RGTLFED	APC,CDC20,FZR1	0.9846	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons