DegronMD

Uniprot ID: P12644

Source protein: Bone morphogenetic protein 4

Source gene: BMP4

Class: LIG_APCC_ABBAyCdc20_2

Location: 310:316

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9029

ASA_SCORE: 71.1143

COIL: 0.4517

CONS_SCORE: 0.794

DSS_SCORE: 0.2836

HELIX: 0.0676

FCONS_SCORE: 1.2508

RIG_SCORE: 0.8155

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R310C	TCGA-14-0867	GBM	TCGA	RHSLYVD	LIG_APCC_ABBAyCdc20_2	0.8301
p.R310C	DO11675	GBM	ICGC	RHSLYVD	LIG_APCC_ABBAyCdc20_2	0.8301
p.K304N	TCGA-22-5481	LUSC	TCGA	RHSLYVD	LIG_APCC_ABBAyCdc20_2	0.2778
p.K304N	DO27160	LUSC	ICGC	RHSLYVD	LIG_APCC_ABBAyCdc20_2	0.2778
p.R300W	TCGA-91-7771	LUAD	TCGA	RHSLYVD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R300W	DO25807	LUAD	ICGC	RHSLYVD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R309L	TCGA-BA-A6DA	HNSC	TCGA	RHSLYVD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R309L	DO44448	HNSC	ICGC	RHSLYVD	LIG_APCC_ABBAyCdc20_2	0.3056
p.D319N	TCGA-BS-A0UF	UCEC	TCGA	RHSLYVD	LIG_APCC_ABBAyCdc20_2	0.25
p.D319N	TCGA-E6-A1LX	UCEC	TCGA	RHSLYVD	LIG_APCC_ABBAyCdc20_2	0.25
p.D319N	DO41020	UCEC	ICGC	RHSLYVD	LIG_APCC_ABBAyCdc20_2	0.25
p.D319N	DO41488	UCEC	ICGC	RHSLYVD	LIG_APCC_ABBAyCdc20_2	0.25
p.D319N	SIDM00583	Pancreatic Carcinoma	GDSC	RHSLYVD	LIG_APCC_ABBAyCdc20_2	0.25
p.D319N	ACH-000164	Pancreatic Cancer	CCLE	RHSLYVD	LIG_APCC_ABBAyCdc20_2	0.25
p.D319N	ACH-001107	Pancreatic Cancer	CCLE	RHSLYVD	LIG_APCC_ABBAyCdc20_2	0.25
p.D319N	KP-1N	pancreas	COSMIC	RHSLYVD	LIG_APCC_ABBAyCdc20_2	0.25
p.R309Q	TCGA-CM-4743	COAD	TCGA	RHSLYVD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R309Q	DO8103	COAD	ICGC	RHSLYVD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R310H	TCGA-D1-A103	UCEC	TCGA	RHSLYVD	LIG_APCC_ABBAyCdc20_2	0.8244
p.R310H	DO42312	UCEC	ICGC	RHSLYVD	LIG_APCC_ABBAyCdc20_2	0.8244
p.V315A	TCGA-DF-A2KU	UCEC	TCGA	RHSLYVD	LIG_APCC_ABBAyCdc20_2	0.5825
p.V315A	DO223286	UCEC	ICGC	RHSLYVD	LIG_APCC_ABBAyCdc20_2	0.5825
p.W322L	TCGA-EE-A3AC	SKCM	TCGA	RHSLYVD	LIG_APCC_ABBAyCdc20_2	0.1667
p.W322L	DO37631	SKCM	ICGC	RHSLYVD	LIG_APCC_ABBAyCdc20_2	0.1667
p.N323D	DO224756	LAML	ICGC	RHSLYVD	LIG_APCC_ABBAyCdc20_2	0.1389
p.S318N	SIDM00721	Small Cell Lung Carcinoma	GDSC	RHSLYVD	LIG_APCC_ABBAyCdc20_2	0.2778
p.S318N	ACH-002171	Lung Cancer	CCLE	RHSLYVD	LIG_APCC_ABBAyCdc20_2	0.2778
p.S318N	NCI-H250	lung	COSMIC	RHSLYVD	LIG_APCC_ABBAyCdc20_2	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RHSLYVD

Degron related mutations and impact score

Drug responses associated with BMP4 mutations

All proteins holding degron of RHSLYVD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12644	Bone morphogenetic protein 4	LIG_APCC_ABBAyCdc20_2	310:316	RHSLYVD	APC,CDC20,FZR1	0.9029	More...