DegronMD

Uniprot ID: Q5T5Y3

Source protein: Calmodulin-regulated spectrin-associated protein 1

Source gene: CAMSAP1

Class: LIG_APCC_ABBAyCdc20_2

Location: 397:403

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9506

ASA_SCORE: 101

COIL: 0.8163

CONS_SCORE: 0.3836

DSS_SCORE: 0.4899

HELIX: 0.1096

FCONS_SCORE: 1.004

RIG_SCORE: 0.704

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V399M	DO23774	LUAD	ICGC	RHYLHPE	LIG_APCC_ABBAyCdc20_2	0.7208
p.V399M	C-33-A	cervix	COSMIC	RHYLHPE	LIG_APCC_ABBAyCdc20_2	0.7208
p.V399M	SAS	upper_aerodigestive_tract	COSMIC	RHYLHPE	LIG_APCC_ABBAyCdc20_2	0.7208
p.A397T	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	RHYLHPE	LIG_APCC_ABBAyCdc20_2	0.7139
p.Y399H	SIDM00656	Burkitt's Lymphoma	GDSC	RHYLHPE	LIG_APCC_ABBAyCdc20_2	0.6118
p.Y399H	SIDM00529	Breast Carcinoma	GDSC	RHYLHPE	LIG_APCC_ABBAyCdc20_2	0.6118
p.Y399H	SIDM01039	Other Solid Cancers	GDSC	RHYLHPE	LIG_APCC_ABBAyCdc20_2	0.6118
p.Y399H	SIDM00878	Breast Carcinoma	GDSC	RHYLHPE	LIG_APCC_ABBAyCdc20_2	0.6118
p.Y399H	SIDM00493	Other Solid Cancers	GDSC	RHYLHPE	LIG_APCC_ABBAyCdc20_2	0.6118
p.Y399H	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	RHYLHPE	LIG_APCC_ABBAyCdc20_2	0.6118
p.Y399H	SIDM00641	Burkitt's Lymphoma	GDSC	RHYLHPE	LIG_APCC_ABBAyCdc20_2	0.6118
p.Y410C	DO228901	LICA	ICGC	RHYLHPE	LIG_APCC_ABBAyCdc20_2	0.25
p.L408P	SIDM00333	Endometrial Carcinoma	GDSC	RHYLHPE	LIG_APCC_ABBAyCdc20_2	0.1944
p.L408P	MFE-319	endometrium	COSMIC	RHYLHPE	LIG_APCC_ABBAyCdc20_2	0.1944
p.V388M	TCGA-53-7626	LUAD	TCGA	RHYLHPE	LIG_APCC_ABBAyCdc20_2	0.0833
p.V388M	SIDM00889	Cervical Carcinoma	GDSC	RHYLHPE	LIG_APCC_ABBAyCdc20_2	0.0833
p.V388M	SIDM00351	Oral Cavity Carcinoma	GDSC	RHYLHPE	LIG_APCC_ABBAyCdc20_2	0.0833
p.V388M	ACH-001333	Cervical Cancer	CCLE	RHYLHPE	LIG_APCC_ABBAyCdc20_2	0.0833
p.V388M	ACH-002029	Head and Neck Cancer	CCLE	RHYLHPE	LIG_APCC_ABBAyCdc20_2	0.0833
p.V388M	SAS	upper_aerodigestive_tract	COSMIC	RHYLHPE	LIG_APCC_ABBAyCdc20_2	0.0833
p.V388M	C-33-A	cervix	COSMIC	RHYLHPE	LIG_APCC_ABBAyCdc20_2	0.0833
p.A388S	LS-411N	large_intestine	COSMIC	RHYLHPE	LIG_APCC_ABBAyCdc20_2	0.0833

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Drug responses associated with CAMSAP1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of RHYLHPE

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T5Y3	Calmodulin-regulated spectrin-associated protein 1	LIG_APCC_ABBAyCdc20_2	397:403	RHYLHPE	APC,CDC20,FZR1	0.9506	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RHYLHPE

Degron related mutations and impact score

Drug responses associated with CAMSAP1 mutations

All proteins holding degron of RHYLHPE