DegronMD

Uniprot ID: P98196

Source protein: Phospholipid-transporting ATPase IH

Source gene: ATP11A

Class: LIG_APCC_ABBAyCdc20_2

Location: 229:235

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6174

ASA_SCORE: 50.3429

COIL: 0.3031

CONS_SCORE: 0.3815

DSS_SCORE: 0.1491

HELIX: 0.0087

FCONS_SCORE: 0.6395

RIG_SCORE: 0.8327

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V227M	TCGA-75-5122	LUAD	TCGA	RINVYSD	LIG_APCC_ABBAyCdc20_2	0.2778
p.V227M	TCGA-AJ-A3BH	UCEC	TCGA	RINVYSD	LIG_APCC_ABBAyCdc20_2	0.2778
p.V227M	TCGA-QS-A8F1	UCEC	TCGA	RINVYSD	LIG_APCC_ABBAyCdc20_2	0.2778
p.V227M	DO233207	GACA	ICGC	RINVYSD	LIG_APCC_ABBAyCdc20_2	0.2778
p.V227M	DO23882	LUAD	ICGC	RINVYSD	LIG_APCC_ABBAyCdc20_2	0.2778
p.V227M	DO219783	UCEC	ICGC	RINVYSD	LIG_APCC_ABBAyCdc20_2	0.2778
p.V227M	DO41638	UCEC	ICGC	RINVYSD	LIG_APCC_ABBAyCdc20_2	0.2778
p.V232I	TCGA-A5-A1OF	UCEC	TCGA	RINVYSD	LIG_APCC_ABBAyCdc20_2	0.5965
p.V232I	DO42568	UCEC	ICGC	RINVYSD	LIG_APCC_ABBAyCdc20_2	0.5965
p.R229H	TCGA-E2-A10B	BRCA	TCGA	RINVYSD	LIG_APCC_ABBAyCdc20_2	0.8244
p.R229H	DO5843	BRCA	ICGC	RINVYSD	LIG_APCC_ABBAyCdc20_2	0.8244
p.R229C	TCGA-EE-A2MR	SKCM	TCGA	RINVYSD	LIG_APCC_ABBAyCdc20_2	0.8301
p.R229C	DO232224	PBCA	ICGC	RINVYSD	LIG_APCC_ABBAyCdc20_2	0.8301
p.R229C	DO37819	SKCM	ICGC	RINVYSD	LIG_APCC_ABBAyCdc20_2	0.8301
p.R242G	DO222637	BTCA	ICGC	RINVYSD	LIG_APCC_ABBAyCdc20_2	0.1389
p.G245E	DO233237	GACA	ICGC	RINVYSD	LIG_APCC_ABBAyCdc20_2	0.0556
p.V241L	DO228974	LICA	ICGC	RINVYSD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R229L	DO228976	LICA	ICGC	RINVYSD	LIG_APCC_ABBAyCdc20_2	0.8428
p.V227L	DO228978	LICA	ICGC	RINVYSD	LIG_APCC_ABBAyCdc20_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98196	Phospholipid-transporting ATPase IH	LIG_APCC_ABBAyCdc20_2	229:235	RINVYSD	APC,CDC20,FZR1	0.6174	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons