DegronMD

Uniprot ID: Q9NVL8

Source protein: Uncharacterized protein CCDC198

Source gene: CCDC198

Class: LIG_APCC_ABBAyCdc20_2

Location: 285:291

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8218

ASA_SCORE: 79.3143

COIL: 0.6887

CONS_SCORE: 0.6937

DSS_SCORE: 0.5362

HELIX: 0.2041

FCONS_SCORE: 1.0041

RIG_SCORE: 0.825

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G281C	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	RIPLFDE	LIG_APCC_ABBAyCdc20_2	0.6667
p.G281C	HARA	lung	COSMIC	RIPLFDE	LIG_APCC_ABBAyCdc20_2	0.6667
p.I280T	SIDM00311	Mesothelioma	GDSC	RIPLFDE	LIG_APCC_ABBAyCdc20_2	0.1944
p.I280T	SIDM00097	Breast Carcinoma	GDSC	RIPLFDE	LIG_APCC_ABBAyCdc20_2	0.1944
p.I280T	SIDM00479	Esophageal Carcinoma	GDSC	RIPLFDE	LIG_APCC_ABBAyCdc20_2	0.1944
p.H288R	SIDM00694	Other Solid Cancers	GDSC	RIPLFDE	LIG_APCC_ABBAyCdc20_2	0.8244
p.H288R	HUTU-80	small_intestine	COSMIC	RIPLFDE	LIG_APCC_ABBAyCdc20_2	0.8244
p.D299E	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	RIPLFDE	LIG_APCC_ABBAyCdc20_2	0.1111
p.D293E	Becker	central_nervous_system	COSMIC	RIPLFDE	LIG_APCC_ABBAyCdc20_2	0.2778
p.D294E	Becker	central_nervous_system	COSMIC	RIPLFDE	LIG_APCC_ABBAyCdc20_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NVL8	Uncharacterized protein CCDC198	LIG_APCC_ABBAyCdc20_2	285:291	RIPLFDE	APC,CDC20,FZR1	0.8218	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons