DegronMD - Q9NVL8(CCDC198)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G281C	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	IPLFDE	LIG_APCC_ABBA_1	286:291	Mutation blocking phosphorylation signal	0.6389
p.G281C	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	RIPLFDE	LIG_APCC_ABBAyCdc20_2	285:291	Mutation blocking phosphorylation signal	0.6667
p.G281C	HARA	lung	COSMIC	IPLFDE	LIG_APCC_ABBA_1	286:291	Mutation blocking phosphorylation signal	0.6389
p.G281C	HARA	lung	COSMIC	RIPLFDE	LIG_APCC_ABBAyCdc20_2	285:291	Mutation blocking phosphorylation signal	0.6667
p.I280T	SIDM00311	Mesothelioma	GDSC	IPLFDE	LIG_APCC_ABBA_1	286:291	Mutation rewiring degron network	0.1667
p.I280T	SIDM00311	Mesothelioma	GDSC	RIPLFDE	LIG_APCC_ABBAyCdc20_2	285:291	Mutation rewiring degron network	0.1944
p.I280T	SIDM00097	Breast Carcinoma	GDSC	IPLFDE	LIG_APCC_ABBA_1	286:291	Mutation rewiring degron network	0.1667
p.I280T	SIDM00097	Breast Carcinoma	GDSC	RIPLFDE	LIG_APCC_ABBAyCdc20_2	285:291	Mutation rewiring degron network	0.1944
p.I280T	SIDM00479	Esophageal Carcinoma	GDSC	IPLFDE	LIG_APCC_ABBA_1	286:291	Mutation rewiring degron network	0.1667
p.I280T	SIDM00479	Esophageal Carcinoma	GDSC	RIPLFDE	LIG_APCC_ABBAyCdc20_2	285:291	Mutation rewiring degron network	0.1944
p.H288R	SIDM00694	Other Solid Cancers	GDSC	IPLFDE	LIG_APCC_ABBA_1	286:291	Mutation altering degron motif	0.8244
p.H288R	SIDM00694	Other Solid Cancers	GDSC	RIPLFDE	LIG_APCC_ABBAyCdc20_2	285:291	Mutation altering degron motif	0.8244
p.H288R	HUTU-80	small intestine	COSMIC	IPLFDE	LIG_APCC_ABBA_1	286:291	Mutation altering degron motif	0.8244
p.H288R	HUTU-80	small intestine	COSMIC	RIPLFDE	LIG_APCC_ABBAyCdc20_2	285:291	Mutation altering degron motif	0.8244
p.M158T	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	NRQYLHKMQ	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.25
p.M158T	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	NRQYLHKMQ	DEG_APCC_DBOX_1	147:155	Mutation rewiring degron network	0.25
p.D299E	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	IPLFDE	LIG_APCC_ABBA_1	286:291	Mutation rewiring degron network	0.1111
p.D299E	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	RIPLFDE	LIG_APCC_ABBAyCdc20_2	285:291	Mutation rewiring degron network	0.1111
p.D293E	Becker	central nervous system	COSMIC	IPLFDE	LIG_APCC_ABBA_1	286:291	Mutation rewiring degron network	0.2778
p.D293E	Becker	central nervous system	COSMIC	RIPLFDE	LIG_APCC_ABBAyCdc20_2	285:291	Mutation rewiring degron network	0.2778
p.D294E	Becker	central nervous system	COSMIC	IPLFDE	LIG_APCC_ABBA_1	286:291	Mutation rewiring degron network	0.25
p.D294E	Becker	central nervous system	COSMIC	RIPLFDE	LIG_APCC_ABBAyCdc20_2	285:291	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC198

UniProt ID: Q9NVL8

Entrez ID: 55195

Protein name: Uncharacterized protein CCDC198

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC198 in