DegronMD

Uniprot ID: A6NFK2

Source protein: Glutaredoxin domain-containing cysteine-rich protein 2

Source gene: GRXCR2

Class: LIG_APCC_ABBAyCdc20_2

Location: 84:90

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7784

ASA_SCORE: 80.4857

COIL: 0.4019

CONS_SCORE: 0.5432

DSS_SCORE: 0.3341

HELIX: 0.0711

FCONS_SCORE: 1.1371

RIG_SCORE: 0.8241

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G98D	DO234285	ESAD	ICGC	RISVFRE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R84K	DO222908	MELA	ICGC	RISVFRE	LIG_APCC_ABBAyCdc20_2	0.6126
p.P78S	DO218849	SKCA	ICGC	RISVFRE	LIG_APCC_ABBAyCdc20_2	0.1667
p.S77F	DO229502	SKCA	ICGC	RISVFRE	LIG_APCC_ABBAyCdc20_2	0.1389
p.G98C	SIDM00061	Ovarian Carcinoma	GDSC	RISVFRE	LIG_APCC_ABBAyCdc20_2	0.1111
p.G98C	SIDM01095	Rhabdomyosarcoma	GDSC	RISVFRE	LIG_APCC_ABBAyCdc20_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NFK2	Glutaredoxin domain-containing cysteine-rich protein 2	LIG_APCC_ABBAyCdc20_2	84:90	RISVFRE	APC,CDC20,FZR1	0.7784	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons