DegronMD

Uniprot ID: Q5M9Q1

Source protein: NKAP-like protein

Source gene: NKAPL

Class: DEG_APCC_KENBOX_2

Location: 355:359

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9953

ASA_SCORE: 109.7

COIL: 0.5554

CONS_SCORE: 0.8887

DSS_SCORE: 0.376

HELIX: 0.41

FCONS_SCORE: 1.1022

RIG_SCORE: 0.7605

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R347H	TCGA-13-2057	OV	TCGA	RKENQ	DEG_APCC_KENBOX_2	0.1111
p.R347H	TCGA-AA-3492	COAD	TCGA	RKENQ	DEG_APCC_KENBOX_2	0.1111
p.R347H	TCGA-AA-3864	COAD	TCGA	RKENQ	DEG_APCC_KENBOX_2	0.1111
p.R347H	DO8490	COAD	ICGC	RKENQ	DEG_APCC_KENBOX_2	0.1111
p.R347H	DO8224	COAD	ICGC	RKENQ	DEG_APCC_KENBOX_2	0.1111
p.R347H	DO233737	GACA	ICGC	RKENQ	DEG_APCC_KENBOX_2	0.1111
p.R347H	DO31320	OV	ICGC	RKENQ	DEG_APCC_KENBOX_2	0.1111
p.R355C	TCGA-59-2349	OV	TCGA	RKENQ	DEG_APCC_KENBOX_2	0.719
p.R355C	TCGA-CR-7402	HNSC	TCGA	RKENQ	DEG_APCC_KENBOX_2	0.719
p.R355C	DO15727	HNSC	ICGC	RKENQ	DEG_APCC_KENBOX_2	0.719
p.R355C	DO28621	OV	ICGC	RKENQ	DEG_APCC_KENBOX_2	0.719
p.R353Q	TCGA-BR-8360	STAD	TCGA	RKENQ	DEG_APCC_KENBOX_2	0.2778
p.R353Q	TCGA-EO-A3B0	UCEC	TCGA	RKENQ	DEG_APCC_KENBOX_2	0.2778
p.R353Q	DO47745	STAD	ICGC	RKENQ	DEG_APCC_KENBOX_2	0.2778
p.R353Q	DO219773	UCEC	ICGC	RKENQ	DEG_APCC_KENBOX_2	0.2778
p.E365D	TCGA-D1-A17Q	UCEC	TCGA	RKENQ	DEG_APCC_KENBOX_2	0.1667
p.E365D	DO41903	UCEC	ICGC	RKENQ	DEG_APCC_KENBOX_2	0.1667
p.R355H	TCGA-F4-6461	COAD	TCGA	RKENQ	DEG_APCC_KENBOX_2	0.7133
p.R355H	DO10662	COAD	ICGC	RKENQ	DEG_APCC_KENBOX_2	0.7133
p.R355H	SIDM02013	Colorectal Carcinoma	GDSC	RKENQ	DEG_APCC_KENBOX_2	0.7133
p.L369I	TCGA-IB-7651	PAAD	TCGA	RKENQ	DEG_APCC_KENBOX_2	0.0556
p.L369I	DO46657	PAAD	ICGC	RKENQ	DEG_APCC_KENBOX_2	0.0556
p.K366N	TCGA-JW-A5VL	CESC	TCGA	RKENQ	DEG_APCC_KENBOX_2	0.5833
p.K366N	DO49976	CESC	ICGC	RKENQ	DEG_APCC_KENBOX_2	0.5833
p.E365K	TCGA-K4-A5RH	BLCA	TCGA	RKENQ	DEG_APCC_KENBOX_2	0.1667
p.E365K	DO219028	BLCA	ICGC	RKENQ	DEG_APCC_KENBOX_2	0.1667
p.R348G	DO233781	GACA	ICGC	RKENQ	DEG_APCC_KENBOX_2	0.1389
p.L354V	SIDM00581	Glioblastoma	GDSC	RKENQ	DEG_APCC_KENBOX_2	0.3056
p.L354V	SIDM00549	B-Lymphoblastic Leukemia	GDSC	RKENQ	DEG_APCC_KENBOX_2	0.3056
p.L354V	SIDM00655	Other Solid Cancers	GDSC	RKENQ	DEG_APCC_KENBOX_2	0.3056
p.L354V	SIDM01187	Breast Carcinoma	GDSC	RKENQ	DEG_APCC_KENBOX_2	0.3056
p.L354V	SIDM00349	Esophageal Squamous Cell Carcinoma	GDSC	RKENQ	DEG_APCC_KENBOX_2	0.3056
p.L354V	SIDM01617	Endometrial Carcinoma	GDSC	RKENQ	DEG_APCC_KENBOX_2	0.3056
p.L354V	SIDM01469	Pancreatic Carcinoma	GDSC	RKENQ	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N5F7	NF-kappa-B-activating protein	DEG_APCC_KENBOX_2	368:372	RKENQ	APC,CDC20,FZR1	0.9954	More...
Q5M9Q1	NKAP-like protein	DEG_APCC_KENBOX_2	355:359	RKENQ	APC,CDC20,FZR1	0.9953	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RKENQ

Degron related mutations and impact score

Drug responses associated with NKAPL mutations

All proteins holding degron of RKENQ