DegronMD

Uniprot ID: Q8N5F7

Source protein: NF-kappa-B-activating protein

Source gene: NKAP

Class: DEG_APCC_KENBOX_2

Location: 368:372

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9954

ASA_SCORE: 108.22

COIL: 0.5702

CONS_SCORE: 0.8768

DSS_SCORE: 0.369

HELIX: 0.399

FCONS_SCORE: 1.1107

RIG_SCORE: 0.7573

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R368Q	TCGA-A5-A0GA	UCEC	TCGA	RKENQ	DEG_APCC_KENBOX_2	0.6218
p.R368Q	TCGA-E6-A1LX	UCEC	TCGA	RKENQ	DEG_APCC_KENBOX_2	0.6218
p.R368Q	TCGA-EK-A2PG	CESC	TCGA	RKENQ	DEG_APCC_KENBOX_2	0.6218
p.R368Q	TCGA-EO-A3L0	UCEC	TCGA	RKENQ	DEG_APCC_KENBOX_2	0.6218
p.R368Q	TCGA-OL-A66J	BRCA	TCGA	RKENQ	DEG_APCC_KENBOX_2	0.6218
p.R368Q	DO44153	BRCA	ICGC	RKENQ	DEG_APCC_KENBOX_2	0.6218
p.R368Q	DO49939	CESC	ICGC	RKENQ	DEG_APCC_KENBOX_2	0.6218
p.R368Q	DO219775	UCEC	ICGC	RKENQ	DEG_APCC_KENBOX_2	0.6218
p.R368Q	DO41020	UCEC	ICGC	RKENQ	DEG_APCC_KENBOX_2	0.6218
p.R368Q	DO43763	UCEC	ICGC	RKENQ	DEG_APCC_KENBOX_2	0.6218
p.R361Q	TCGA-AG-3892	READ	TCGA	RKENQ	DEG_APCC_KENBOX_2	0.1389
p.R361Q	DO36394	READ	ICGC	RKENQ	DEG_APCC_KENBOX_2	0.1389
p.R361Q	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	RKENQ	DEG_APCC_KENBOX_2	0.1389
p.R361Q	ACH-001638	Lymphoma	CCLE	RKENQ	DEG_APCC_KENBOX_2	0.1389
p.R361Q	RC-K8	haematopoietic_and_lymphoid_tissue	COSMIC	RKENQ	DEG_APCC_KENBOX_2	0.1389
p.R366Q	TCGA-BG-A0MI	UCEC	TCGA	RKENQ	DEG_APCC_KENBOX_2	0.2778
p.R366Q	TCGA-MX-A5UG	STAD	TCGA	RKENQ	DEG_APCC_KENBOX_2	0.2778
p.R366Q	DO50867	LICA	ICGC	RKENQ	DEG_APCC_KENBOX_2	0.2778
p.R366Q	DO48514	STAD	ICGC	RKENQ	DEG_APCC_KENBOX_2	0.2778
p.R366Q	DO40912	UCEC	ICGC	RKENQ	DEG_APCC_KENBOX_2	0.2778
p.N371K	TCGA-G3-A3CG	LIHC	TCGA	RKENQ	DEG_APCC_KENBOX_2	0.6918
p.N371K	DO22845	LIHC	ICGC	RKENQ	DEG_APCC_KENBOX_2	0.6918
p.R360C	DO225367	BRCA	ICGC	RKENQ	DEG_APCC_KENBOX_2	0.1111
p.M362L	DO222404	BTCA	ICGC	RKENQ	DEG_APCC_KENBOX_2	0.1667
p.Q372H	DO20416	KIRC	ICGC	RKENQ	DEG_APCC_KENBOX_2	0.647
p.E370G	DO46769	PAEN	ICGC	RKENQ	DEG_APCC_KENBOX_2	0.7199

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N5F7	NF-kappa-B-activating protein	DEG_APCC_KENBOX_2	368:372	RKENQ	APC,CDC20,FZR1	0.9954	More...
Q5M9Q1	NKAP-like protein	DEG_APCC_KENBOX_2	355:359	RKENQ	APC,CDC20,FZR1	0.9953	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons