DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
RKGLYVE
Uniprot ID:
Q7Z2Z2
Source protein:
Elongation factor-like GTPase 1
Source gene:
EFL1
Class:
LIG_APCC_ABBAyCdc20_2
Location:
1097:1103
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5861
ASA_SCORE:
87.3571
COIL:
0.6949
CONS_SCORE:
0.7925
DSS_SCORE:
0.29
HELIX:
0.2661
FCONS_SCORE:
1.1158
RIG_SCORE:
0.7902
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.N1092D
SIDM01045
Endometrial Carcinoma
GDSC
RKGLYVE
LIG_APCC_ABBAyCdc20_2
0.1944
p.N1092D
EN
endometrium
COSMIC
RKGLYVE
LIG_APCC_ABBAyCdc20_2
0.1944
Drug responses associated with EFL1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RKGLYVE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q7Z2Z2
Elongation factor-like GTPase 1
LIG_APCC_ABBAyCdc20_2
1097:1103
RKGLYVE
APC,CDC20,FZR1
0.5861
More...