EFL1
UniProt ID: Q7Z2Z2
Entrez ID: 79631
Protein name: Elongation factor-like GTPase 1 (Elongation factor Tu GTP-binding domain-containing protein 1) (Elongation factor-like 1) (Protein FAM42A)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assemb...
FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. Together with SBDS, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Has low intrinsic GTPase activity. GTPase activity is increased by contact with 60S ribosome subunits. {ECO:0000269|PubMed:21536732}.
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GO - Biological processes (BP):
GTP metabolic process [GO:0046039]; mature ribosome assembly [GO:0042256]...
GTP metabolic process [GO:0046039]; mature ribosome assembly [GO:0042256]
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GO - Molecular function (MF):
GTPase activity [GO:0003924]; GTP binding [GO:0005525]; ribosome binding [GO:0043022]; translation elongation factor activity [GO:0003746]...
GTPase activity [GO:0003924]; GTP binding [GO:0005525]; ribosome binding [GO:0043022]; translation elongation factor activity [GO:0003746]
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GO - Cellular component (CC):
ribonucleoprotein complex [GO:1990904]...
ribonucleoprotein complex [GO:1990904]
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EFL1
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*NOTE: the Kaplan plots were collected from OncoLnc