DegronMD

Uniprot ID: Q9NVA4

Source protein: Transmembrane protein 184C

Source gene: TMEM184C

Class: LIG_APCC_ABBAyCdc20_2

Location: 359:365

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7797

ASA_SCORE: 120.9857

COIL: 0.8754

CONS_SCORE: 0.3021

DSS_SCORE: 0.6577

HELIX: 0.0754

FCONS_SCORE: 0.8113

RIG_SCORE: 0.7043

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R352Q	TCGA-AP-A059	UCEC	TCGA	RKKLFPE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R352Q	DO41361	UCEC	ICGC	RKKLFPE	LIG_APCC_ABBAyCdc20_2	0.1389
p.F363C	TCGA-BP-5173	KIRC	TCGA	RKKLFPE	LIG_APCC_ABBAyCdc20_2	0.7108
p.F363C	DO20289	KIRC	ICGC	RKKLFPE	LIG_APCC_ABBAyCdc20_2	0.7108
p.P358H	TCGA-ER-A19B	SKCM	TCGA	RKKLFPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.P358H	DO47491	SKCM	ICGC	RKKLFPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.D366Y	TCGA-JX-A3PZ	CESC	TCGA	RKKLFPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.D366Y	DO51606	CESC	ICGC	RKKLFPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.D368Y	DO228338	MALY	ICGC	RKKLFPE	LIG_APCC_ABBAyCdc20_2	0.25
p.L362M	SIDM01016	T-Lymphoblastic Leukemia	GDSC	RKKLFPE	LIG_APCC_ABBAyCdc20_2	0.5999
p.L362M	ACH-000995	Leukemia	CCLE	RKKLFPE	LIG_APCC_ABBAyCdc20_2	0.5999
p.L362M	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	RKKLFPE	LIG_APCC_ABBAyCdc20_2	0.5999
p.E365G	SIDM01617	Endometrial Carcinoma	GDSC	RKKLFPE	LIG_APCC_ABBAyCdc20_2	0.7199
p.E365G	ACH-000994	Endometrial/Uterine Cancer	CCLE	RKKLFPE	LIG_APCC_ABBAyCdc20_2	0.7199
p.V354A	ACH-001461	Colon/Colorectal Cancer	CCLE	RKKLFPE	LIG_APCC_ABBAyCdc20_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NVA4	Transmembrane protein 184C	LIG_APCC_ABBAyCdc20_2	359:365	RKKLFPE	APC,CDC20,FZR1	0.7797	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons