DegronMD - Q9NVA4(TMEM184C)

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R352Q	TCGA-AP-A059	UCEC	TCGA	RKKLFPE	LIG_APCC_ABBAyCdc20_2	359:365	Mutation rewiring degron network	0.1389
p.R352Q	DO41361	UCEC	ICGC	RKKLFPE	LIG_APCC_ABBAyCdc20_2	359:365	Mutation rewiring degron network	0.1389
p.F363C	TCGA-BP-5173	KIRC	TCGA	RKKLFPE	LIG_APCC_ABBAyCdc20_2	359:365	Mutation altering degron motif	0.7108
p.F363C	DO20289	KIRC	ICGC	RKKLFPE	LIG_APCC_ABBAyCdc20_2	359:365	Mutation altering degron motif	0.7108
p.P358H	TCGA-ER-A19B	SKCM	TCGA	RKKLFPE	LIG_APCC_ABBAyCdc20_2	359:365	Mutation rewiring degron network	0.3056
p.P358H	DO47491	SKCM	ICGC	RKKLFPE	LIG_APCC_ABBAyCdc20_2	359:365	Mutation rewiring degron network	0.3056
p.Q408K	TCGA-HE-7130	KIRP	TCGA	VTPQTT	DEG_SCF_FBW7_1	405:410	Mutation altering degron motif	0.5833
p.Q408K	DO20776	KIRP	ICGC	VTPQTT	DEG_SCF_FBW7_1	405:410	Mutation altering degron motif	0.5833
p.T404I	TCGA-HT-A61C	LGG	TCGA	VTPQTT	DEG_SCF_FBW7_1	405:410	Mutation rewiring degron network	0.3056
p.T404I	DO219813	LGG	ICGC	VTPQTT	DEG_SCF_FBW7_1	405:410	Mutation rewiring degron network	0.3056
p.D366Y	TCGA-JX-A3PZ	CESC	TCGA	RKKLFPE	LIG_APCC_ABBAyCdc20_2	359:365	Mutation rewiring degron network	0.3056
p.D366Y	DO51606	CESC	ICGC	RKKLFPE	LIG_APCC_ABBAyCdc20_2	359:365	Mutation rewiring degron network	0.3056
p.K415N	TCGA-XF-AAMG	BLCA	TCGA	VTPQTT	DEG_SCF_FBW7_1	405:410	Mutation substituting flanking lysine	0.3056
p.K415N	DO219049	BLCA	ICGC	VTPQTT	DEG_SCF_FBW7_1	405:410	Mutation substituting flanking lysine	0.3056
p.D368Y	DO228338	MALY	ICGC	RKKLFPE	LIG_APCC_ABBAyCdc20_2	359:365	Mutation rewiring degron network	0.25
p.L362M	SIDM01016	T-Lymphoblastic Leukemia	GDSC	RKKLFPE	LIG_APCC_ABBAyCdc20_2	359:365	Mutation altering degron motif	0.5999
p.L362M	ACH-000995	Leukemia	CCLE	RKKLFPE	LIG_APCC_ABBAyCdc20_2	359:365	Mutation altering degron motif	0.5999
p.L362M	Jurkat	haematopoietic and lymphoid tissue	COSMIC	RKKLFPE	LIG_APCC_ABBAyCdc20_2	359:365	Mutation altering degron motif	0.5999
p.E365G	SIDM01617	Endometrial Carcinoma	GDSC	RKKLFPE	LIG_APCC_ABBAyCdc20_2	359:365	Mutation altering degron motif	0.7199
p.E365G	ACH-000994	Endometrial/Uterine Cancer	CCLE	RKKLFPE	LIG_APCC_ABBAyCdc20_2	359:365	Mutation altering degron motif	0.7199
p.H397R	ACH-000961	Endometrial/Uterine Cancer	CCLE	VTPQTT	DEG_SCF_FBW7_1	405:410	Mutation rewiring degron network	0.1111
p.Y398C	ACH-000961	Endometrial/Uterine Cancer	CCLE	VTPQTT	DEG_SCF_FBW7_1	405:410	Mutation blocking phosphorylation signal	0.5833
p.V354A	ACH-001461	Colon/Colorectal Cancer	CCLE	RKKLFPE	LIG_APCC_ABBAyCdc20_2	359:365	Mutation rewiring degron network	0.1944
p.V405A	ACH-001610	Brain Cancer	CCLE	VTPQTT	DEG_SCF_FBW7_1	405:410	Mutation altering degron motif	0.6936

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMEM184C

UniProt ID: Q9NVA4

Entrez ID: 55751

Protein name: Transmembrane protein 184C (Transmembrane protein 34)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMEM184C in