DegronMD

Uniprot ID: Q9NVA4

Source protein: Transmembrane protein 184C

Source gene: TMEM184C

Class: DEG_SCF_FBW7_1

Location: 405:410

E3 ligase: FBXW7

DEGRON score: 0.971

ASA_SCORE: 83.0667

COIL: 0.8927

CONS_SCORE: 0.3174

DSS_SCORE: 0.5873

HELIX: 0.0162

FCONS_SCORE: 0.9611

RIG_SCORE: 0.6741

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q408K	TCGA-HE-7130	KIRP	TCGA	VTPQTT	DEG_SCF_FBW7_1	0.5833
p.Q408K	DO20776	KIRP	ICGC	VTPQTT	DEG_SCF_FBW7_1	0.5833
p.T404I	TCGA-HT-A61C	LGG	TCGA	VTPQTT	DEG_SCF_FBW7_1	0.3056
p.T404I	DO219813	LGG	ICGC	VTPQTT	DEG_SCF_FBW7_1	0.3056
p.K415N	TCGA-XF-AAMG	BLCA	TCGA	VTPQTT	DEG_SCF_FBW7_1	0.3056
p.K415N	DO219049	BLCA	ICGC	VTPQTT	DEG_SCF_FBW7_1	0.3056
p.H397R	ACH-000961	Endometrial/Uterine Cancer	CCLE	VTPQTT	DEG_SCF_FBW7_1	0.1111
p.Y398C	ACH-000961	Endometrial/Uterine Cancer	CCLE	VTPQTT	DEG_SCF_FBW7_1	0.5833
p.V405A	ACH-001610	Brain Cancer	CCLE	VTPQTT	DEG_SCF_FBW7_1	0.6936

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NVA4	Transmembrane protein 184C	DEG_SCF_FBW7_1	405:410	VTPQTT	FBXW7	0.971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons