DegronMD

Uniprot ID: Q9NQZ2

Source protein: Something about silencing protein 10

Source gene: UTP3

Class: LIG_APCC_ABBAyCdc20_2

Location: 132:138

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9913

ASA_SCORE: 68.4714

COIL: 0.5483

CONS_SCORE: 0.4253

DSS_SCORE: 0.4833

HELIX: 0.3434

FCONS_SCORE: 1.3506

RIG_SCORE: 0.759

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V123M	TCGA-66-2794	LUSC	TCGA	RKKLYYD	LIG_APCC_ABBAyCdc20_2	0.0833
p.V123M	DO26683	LUSC	ICGC	RKKLYYD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R148W	TCGA-A5-A0G2	UCEC	TCGA	RKKLYYD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R148W	DO41235	UCEC	ICGC	RKKLYYD	LIG_APCC_ABBAyCdc20_2	0.0556
p.R146P	TCGA-E7-A7DV	BLCA	TCGA	RKKLYYD	LIG_APCC_ABBAyCdc20_2	0.1111
p.R146P	DO48583	BLCA	ICGC	RKKLYYD	LIG_APCC_ABBAyCdc20_2	0.1111
p.R146Q	TCGA-VR-A8EW	ESCA	TCGA	RKKLYYD	LIG_APCC_ABBAyCdc20_2	0.1111
p.T139M	DO228313	LICA	ICGC	RKKLYYD	LIG_APCC_ABBAyCdc20_2	0.75
p.Y141C	DO229234	THCA	ICGC	RKKLYYD	LIG_APCC_ABBAyCdc20_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NQZ2	Something about silencing protein 10	LIG_APCC_ABBAyCdc20_2	132:138	RKKLYYD	APC,CDC20,FZR1	0.9913	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons