DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
RKLVFDD
Uniprot ID:
Q5W0B1
Source protein:
ORC ubiquitin ligase 1
Source gene:
OBI1
Class:
LIG_APCC_ABBAyCdc20_2
Location:
424:430
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9923
ASA_SCORE:
85.8429
COIL:
0.518
CONS_SCORE:
0.4366
DSS_SCORE:
0.3891
HELIX:
0.3383
FCONS_SCORE:
1.235
RIG_SCORE:
0.8105
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with OBI1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RKLVFDD
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q5W0B1
ORC ubiquitin ligase 1
LIG_APCC_ABBAyCdc20_2
424:430
RKLVFDD
APC,CDC20,FZR1
0.9923
More...