DegronMD

Uniprot ID: O95822

Source protein: Malonyl-CoA decarboxylase, mitochondrial

Source gene: MLYCD

Class: LIG_APCC_ABBAyCdc20_2

Location: 351:357

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5768

ASA_SCORE: 87.7

COIL: 0.6667

CONS_SCORE: 0.3676

DSS_SCORE: 0.4428

HELIX: 0.2864

FCONS_SCORE: 1.1126

RIG_SCORE: 0.7697

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S344L	TCGA-A5-A2K5	UCEC	TCGA	RNELFTD	LIG_APCC_ABBAyCdc20_2	0.1389
p.S344L	DO41379	UCEC	ICGC	RNELFTD	LIG_APCC_ABBAyCdc20_2	0.1389
p.S358L	TCGA-AX-A0J0	UCEC	TCGA	RNELFTD	LIG_APCC_ABBAyCdc20_2	0.3056
p.S358L	DO41133	UCEC	ICGC	RNELFTD	LIG_APCC_ABBAyCdc20_2	0.3056
p.E359K	TCGA-C8-A26Y	BRCA	TCGA	RNELFTD	LIG_APCC_ABBAyCdc20_2	0.2778
p.E359K	DO1273	BRCA	ICGC	RNELFTD	LIG_APCC_ABBAyCdc20_2	0.2778
p.S364L	TCGA-GN-A26C	SKCM	TCGA	RNELFTD	LIG_APCC_ABBAyCdc20_2	0.1389
p.S364L	DO37782	SKCM	ICGC	RNELFTD	LIG_APCC_ABBAyCdc20_2	0.1389
p.E348D	TCGA-WQ-AB4B	LIHC	TCGA	RNELFTD	LIG_APCC_ABBAyCdc20_2	0.25
p.E348D	DO52327	LIHC	ICGC	RNELFTD	LIG_APCC_ABBAyCdc20_2	0.25
p.E348D	SIDM01056	Breast Carcinoma	GDSC	RNELFTD	LIG_APCC_ABBAyCdc20_2	0.25
p.E348D	SIDM00685	Glioblastoma	GDSC	RNELFTD	LIG_APCC_ABBAyCdc20_2	0.25
p.E348D	SIDM01629	Melanoma	GDSC	RNELFTD	LIG_APCC_ABBAyCdc20_2	0.25
p.E353K	DO234391	ESAD	ICGC	RNELFTD	LIG_APCC_ABBAyCdc20_2	0.591
p.I366N	ACH-001414	Bladder Cancer	CCLE	RNELFTD	LIG_APCC_ABBAyCdc20_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95822	Malonyl-CoA decarboxylase, mitochondrial	LIG_APCC_ABBAyCdc20_2	351:357	RNELFTD	APC,CDC20,FZR1	0.5768	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons