DegronMD - O95822(MLYCD)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S344L	TCGA-A5-A2K5	UCEC	TCGA	RNELFTD	LIG_APCC_ABBAyCdc20_2	351:357	Mutation rewiring degron network	0.1389
p.S344L	DO41379	UCEC	ICGC	RNELFTD	LIG_APCC_ABBAyCdc20_2	351:357	Mutation rewiring degron network	0.1389
p.S358L	TCGA-AX-A0J0	UCEC	TCGA	RNELFTD	LIG_APCC_ABBAyCdc20_2	351:357	Mutation rewiring degron network	0.3056
p.S358L	DO41133	UCEC	ICGC	RNELFTD	LIG_APCC_ABBAyCdc20_2	351:357	Mutation rewiring degron network	0.3056
p.E359K	TCGA-C8-A26Y	BRCA	TCGA	RNELFTD	LIG_APCC_ABBAyCdc20_2	351:357	Mutation rewiring degron network	0.2778
p.E359K	DO1273	BRCA	ICGC	RNELFTD	LIG_APCC_ABBAyCdc20_2	351:357	Mutation rewiring degron network	0.2778
p.S364L	TCGA-GN-A26C	SKCM	TCGA	RNELFTD	LIG_APCC_ABBAyCdc20_2	351:357	Mutation rewiring degron network	0.1389
p.S364L	DO37782	SKCM	ICGC	RNELFTD	LIG_APCC_ABBAyCdc20_2	351:357	Mutation rewiring degron network	0.1389
p.E348D	TCGA-WQ-AB4B	LIHC	TCGA	RNELFTD	LIG_APCC_ABBAyCdc20_2	351:357	Mutation rewiring degron network	0.25
p.E348D	DO52327	LIHC	ICGC	RNELFTD	LIG_APCC_ABBAyCdc20_2	351:357	Mutation rewiring degron network	0.25
p.E348D	SIDM01056	Breast Carcinoma	GDSC	RNELFTD	LIG_APCC_ABBAyCdc20_2	351:357	Mutation rewiring degron network	0.25
p.E348D	SIDM00685	Glioblastoma	GDSC	RNELFTD	LIG_APCC_ABBAyCdc20_2	351:357	Mutation rewiring degron network	0.25
p.E348D	SIDM01629	Melanoma	GDSC	RNELFTD	LIG_APCC_ABBAyCdc20_2	351:357	Mutation rewiring degron network	0.25
p.E353K	DO234391	ESAD	ICGC	RNELFTD	LIG_APCC_ABBAyCdc20_2	351:357	Mutation altering degron motif	0.591
p.I366N	ACH-001414	Bladder Cancer	CCLE	RNELFTD	LIG_APCC_ABBAyCdc20_2	351:357	Mutation rewiring degron network	0.0833
p.M40V	ACH-002348	Non-Cancerous	CCLE	VPPTPAYE	DEG_SCF_FBW7_2	48:55	Mutation rewiring degron network	0.1111

Kaplan plot for MLYCD in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MLYCD

UniProt ID: O95822

Entrez ID: 23417

Protein name: Malonyl-CoA decarboxylase, mitochondrial (MCD) (EC 4.1.1.9)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MLYCD in