DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
RPAAPVLPT
Uniprot ID:
Q9ULH7
Source protein:
Myocardin-related transcription factor B
Source gene:
MRTFB
Class:
DEG_SIAH_1
Location:
244:252
E3 ligase:
SIAH1,SIAH2,SIAH3
DEGRON score:
0.964
ASA_SCORE:
97.5556
COIL:
0.9607
CONS_SCORE:
0.3867
DSS_SCORE:
0.7392
HELIX:
0.0162
FCONS_SCORE:
0.9078
RIG_SCORE:
0.6295
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with MRTFB mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RPAAPVLPT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9ULH7
Myocardin-related transcription factor B
DEG_SIAH_1
244:252
RPAAPVLPT
SIAH1,SIAH2,SIAH3
0.964
More...