DegronMD

Uniprot ID: Q15906

Source protein: Vacuolar protein sorting-associated protein 72 homolog

Source gene: VPS72

Class: LIG_APCC_ABBAyCdc20_2

Location: 297:303

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9757

ASA_SCORE: 66.9286

COIL: 0.6769

CONS_SCORE: 0.8026

DSS_SCORE: 0.265

HELIX: 0.0147

FCONS_SCORE: 1.161

RIG_SCORE: 0.7992

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H307R	TCGA-99-8025	LUAD	TCGA	RPALYRD	LIG_APCC_ABBAyCdc20_2	0.2222
p.H307R	DO24255	LUAD	ICGC	RPALYRD	LIG_APCC_ABBAyCdc20_2	0.2222
p.P290S	TCGA-A5-A0G2	UCEC	TCGA	RPALYRD	LIG_APCC_ABBAyCdc20_2	0.1389
p.P290S	DO41235	UCEC	ICGC	RPALYRD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R293W	TCGA-AA-3864	COAD	TCGA	RPALYRD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R293W	DO8490	COAD	ICGC	RPALYRD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R300C	TCGA-PE-A5DE	BRCA	TCGA	RPALYRD	LIG_APCC_ABBAyCdc20_2	0.8301
p.R300C	DO219643	BRCA	ICGC	RPALYRD	LIG_APCC_ABBAyCdc20_2	0.8301
p.R300C	DO222395	MELA	ICGC	RPALYRD	LIG_APCC_ABBAyCdc20_2	0.8301
p.R300C	DO232224	PBCA	ICGC	RPALYRD	LIG_APCC_ABBAyCdc20_2	0.8301
p.A310D	DO229028	LICA	ICGC	RPALYRD	LIG_APCC_ABBAyCdc20_2	0.1389
p.P298L	DO231683	LINC	ICGC	RPALYRD	LIG_APCC_ABBAyCdc20_2	0.6471
p.L311V	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	RPALYRD	LIG_APCC_ABBAyCdc20_2	0.1111
p.L311V	ACH-000705	Lung Cancer	CCLE	RPALYRD	LIG_APCC_ABBAyCdc20_2	0.1111
p.L311V	ACH-001113	Lung Cancer	CCLE	RPALYRD	LIG_APCC_ABBAyCdc20_2	0.1111
p.L311V	ACH-002156	Lung Cancer	CCLE	RPALYRD	LIG_APCC_ABBAyCdc20_2	0.1111
p.L311V	LC-1-sq	lung	COSMIC	RPALYRD	LIG_APCC_ABBAyCdc20_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15906	Vacuolar protein sorting-associated protein 72 homolog	LIG_APCC_ABBAyCdc20_2	297:303	RPALYRD	APC,CDC20,FZR1	0.9757	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons