DegronMD - Q15906(VPS72)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H307R	TCGA-99-8025	LUAD	TCGA	RPALYRD	LIG_APCC_ABBAyCdc20_2	297:303	Mutation rewiring degron network	0.2222
p.H307R	DO24255	LUAD	ICGC	RPALYRD	LIG_APCC_ABBAyCdc20_2	297:303	Mutation rewiring degron network	0.2222
p.P290S	TCGA-A5-A0G2	UCEC	TCGA	RPALYRD	LIG_APCC_ABBAyCdc20_2	297:303	Mutation rewiring degron network	0.1389
p.P290S	DO41235	UCEC	ICGC	RPALYRD	LIG_APCC_ABBAyCdc20_2	297:303	Mutation rewiring degron network	0.1389
p.R293W	TCGA-AA-3864	COAD	TCGA	RPALYRD	LIG_APCC_ABBAyCdc20_2	297:303	Mutation rewiring degron network	0.2222
p.R293W	DO8490	COAD	ICGC	RPALYRD	LIG_APCC_ABBAyCdc20_2	297:303	Mutation rewiring degron network	0.2222
p.R99Q	TCGA-AJ-A3EL	UCEC	TCGA	VNTPAGS	DEG_SCF_FBW7_1	101:107	Mutation rewiring degron network	0.2778
p.R99Q	DO41542	UCEC	ICGC	VNTPAGS	DEG_SCF_FBW7_1	101:107	Mutation rewiring degron network	0.2778
p.R300C	TCGA-PE-A5DE	BRCA	TCGA	RPALYRD	LIG_APCC_ABBAyCdc20_2	297:303	Mutation altering degron motif	0.8301
p.R300C	DO219643	BRCA	ICGC	RPALYRD	LIG_APCC_ABBAyCdc20_2	297:303	Mutation altering degron motif	0.8301
p.R300C	DO222395	MELA	ICGC	RPALYRD	LIG_APCC_ABBAyCdc20_2	297:303	Mutation altering degron motif	0.8301
p.R300C	DO232224	PBCA	ICGC	RPALYRD	LIG_APCC_ABBAyCdc20_2	297:303	Mutation altering degron motif	0.8301
p.A105T	DO227987	COCA	ICGC	VNTPAGS	DEG_SCF_FBW7_1	101:107	Mutation altering degron motif	0.6028
p.A310D	DO229028	LICA	ICGC	RPALYRD	LIG_APCC_ABBAyCdc20_2	297:303	Mutation rewiring degron network	0.1389
p.P92H	DO229026	LICA	ICGC	VNTPAGS	DEG_SCF_FBW7_1	101:107	Mutation rewiring degron network	0.0833
p.P298L	DO231683	LINC	ICGC	RPALYRD	LIG_APCC_ABBAyCdc20_2	297:303	Mutation altering degron motif	0.6471
p.S107N	SIDM01638	Non-Cancerous	GDSC	VNTPAGS	DEG_SCF_FBW7_1	101:107	Mutation altering degron motif	0.7069
p.L311V	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	RPALYRD	LIG_APCC_ABBAyCdc20_2	297:303	Mutation rewiring degron network	0.1111
p.L311V	ACH-000705	Lung Cancer	CCLE	RPALYRD	LIG_APCC_ABBAyCdc20_2	297:303	Mutation rewiring degron network	0.1111
p.L311V	ACH-001113	Lung Cancer	CCLE	RPALYRD	LIG_APCC_ABBAyCdc20_2	297:303	Mutation rewiring degron network	0.1111
p.L311V	ACH-002156	Lung Cancer	CCLE	RPALYRD	LIG_APCC_ABBAyCdc20_2	297:303	Mutation rewiring degron network	0.1111
p.L311V	LC-1-sq	lung	COSMIC	RPALYRD	LIG_APCC_ABBAyCdc20_2	297:303	Mutation rewiring degron network	0.1111

Kaplan plot for VPS72 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VPS72

UniProt ID: Q15906

Entrez ID: 6944

Protein name: Vacuolar protein sorting-associated protein 72 homolog (Protein YL-1) (Transcription factor-like 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VPS72 in