DegronMD

Uniprot ID: Q15906

Source protein: Vacuolar protein sorting-associated protein 72 homolog

Source gene: VPS72

Class: DEG_SCF_FBW7_1

Location: 101:107

E3 ligase: FBXW7

DEGRON score: 0.978

ASA_SCORE: 82.6571

COIL: 0.9431

CONS_SCORE: 0.4993

DSS_SCORE: 0.6934

HELIX: 0.0369

FCONS_SCORE: 0.8979

RIG_SCORE: 0.6141

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R99Q	TCGA-AJ-A3EL	UCEC	TCGA	VNTPAGS	DEG_SCF_FBW7_1	0.2778
p.R99Q	DO41542	UCEC	ICGC	VNTPAGS	DEG_SCF_FBW7_1	0.2778
p.A105T	DO227987	COCA	ICGC	VNTPAGS	DEG_SCF_FBW7_1	0.6028
p.P92H	DO229026	LICA	ICGC	VNTPAGS	DEG_SCF_FBW7_1	0.0833
p.S107N	SIDM01638	Non-Cancerous	GDSC	VNTPAGS	DEG_SCF_FBW7_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15906	Vacuolar protein sorting-associated protein 72 homolog	DEG_SCF_FBW7_1	101:107	VNTPAGS	FBXW7	0.978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons