DegronMD

Uniprot ID: Q8NCW0

Source protein: Kremen protein 2

Source gene: KREMEN2

Class: LIG_APCC_ABBAyCdc20_2

Location: 58:64

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5837

ASA_SCORE: 47.7714

COIL: 0.6181

CONS_SCORE: 0.4955

DSS_SCORE: 0.504

HELIX: 0.1113

FCONS_SCORE: 1.155

RIG_SCORE: 0.7953

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R50C	TCGA-UF-A7JS	HNSC	TCGA	RPCLFWD	LIG_APCC_ABBAyCdc20_2	0.1111
p.R50C	DO52119	HNSC	ICGC	RPCLFWD	LIG_APCC_ABBAyCdc20_2	0.1111
p.Q65H	DO233262	GACA	ICGC	RPCLFWD	LIG_APCC_ABBAyCdc20_2	0.3056
p.T66S	DO233262	GACA	ICGC	RPCLFWD	LIG_APCC_ABBAyCdc20_2	0.2778
p.G55E	SIDM00617	Hepatocellular Carcinoma	GDSC	RPCLFWD	LIG_APCC_ABBAyCdc20_2	0.25
p.G55E	JHH-2	liver	COSMIC	RPCLFWD	LIG_APCC_ABBAyCdc20_2	0.25
p.S72N	SIDM00510	Small Cell Lung Carcinoma	GDSC	RPCLFWD	LIG_APCC_ABBAyCdc20_2	0.1111
p.S72N	Sarc9371	bone	COSMIC	RPCLFWD	LIG_APCC_ABBAyCdc20_2	0.1111
p.A56S	SIDM00182	Head and Neck Carcinoma	GDSC	RPCLFWD	LIG_APCC_ABBAyCdc20_2	0.2778
p.A56S	ACH-002265	Head and Neck Cancer	CCLE	RPCLFWD	LIG_APCC_ABBAyCdc20_2	0.2778
p.A56S	LB771-HNC	upper_aerodigestive_tract	COSMIC	RPCLFWD	LIG_APCC_ABBAyCdc20_2	0.2778
p.F62L	SIDM01691	Chronic Myelogenous Leukemia	GDSC	RPCLFWD	LIG_APCC_ABBAyCdc20_2	0.6981
p.F62L	ACH-000321	Leukemia	CCLE	RPCLFWD	LIG_APCC_ABBAyCdc20_2	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NCW0	Kremen protein 2	LIG_APCC_ABBAyCdc20_2	58:64	RPCLFWD	APC,CDC20,FZR1	0.5837	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons