DegronMD

Uniprot ID: O75459

Source protein: P antigen family member 1

Source gene: PAGE1

Class: LIG_APCC_ABBAyCdc20_2

Location: 12:18

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9803

ASA_SCORE: 120.0857

COIL: 0.9297

CONS_SCORE: 0.7622

DSS_SCORE: 0.4029

HELIX: 0.0321

FCONS_SCORE: 0.8429

RIG_SCORE: 0.7531

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R10L	TCGA-A5-A1OG	UCEC	TCGA	RPMIYVE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R10L	DO43731	UCEC	ICGC	RPMIYVE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R11C	TCGA-A8-A07C	BRCA	TCGA	RPMIYVE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R11C	DO4713	BRCA	ICGC	RPMIYVE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R11H	TCGA-AX-A2HC	UCEC	TCGA	RPMIYVE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R11H	DO233767	GACA	ICGC	RPMIYVE	LIG_APCC_ABBAyCdc20_2	0.3056
p.R11H	DO41572	UCEC	ICGC	RPMIYVE	LIG_APCC_ABBAyCdc20_2	0.3056
p.Y9H	TCGA-BR-4201	STAD	TCGA	RPMIYVE	LIG_APCC_ABBAyCdc20_2	0.6944
p.Y9H	DO38707	STAD	ICGC	RPMIYVE	LIG_APCC_ABBAyCdc20_2	0.6944
p.L4V	TCGA-D8-A1JJ	BRCA	TCGA	RPMIYVE	LIG_APCC_ABBAyCdc20_2	0.1111
p.L4V	DO4599	BRCA	ICGC	RPMIYVE	LIG_APCC_ABBAyCdc20_2	0.1111
p.G2S	TCGA-D8-A1X9	BRCA	TCGA	RPMIYVE	LIG_APCC_ABBAyCdc20_2	0.0556
p.G2S	DO5472	BRCA	ICGC	RPMIYVE	LIG_APCC_ABBAyCdc20_2	0.0556
p.I8M	TCGA-EK-A2IP	CESC	TCGA	RPMIYVE	LIG_APCC_ABBAyCdc20_2	0.2222
p.I8M	DO48978	CESC	ICGC	RPMIYVE	LIG_APCC_ABBAyCdc20_2	0.2222
p.L7V	TCGA-IB-7646	PAAD	TCGA	RPMIYVE	LIG_APCC_ABBAyCdc20_2	0.1944
p.L7V	DO46649	PAAD	ICGC	RPMIYVE	LIG_APCC_ABBAyCdc20_2	0.1944
p.Y9N	TCGA-R8-A73M	LGG	TCGA	RPMIYVE	LIG_APCC_ABBAyCdc20_2	0.6944
p.Y9N	DO48591	LGG	ICGC	RPMIYVE	LIG_APCC_ABBAyCdc20_2	0.6944
p.M14T	DO228207	LICA	ICGC	RPMIYVE	LIG_APCC_ABBAyCdc20_2	0.6312
p.D25A	DO48732	LIRI	ICGC	RPMIYVE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R10W	DO222644	MELA	ICGC	RPMIYVE	LIG_APCC_ABBAyCdc20_2	0.2778
p.M14I	DO51050	PRAD	ICGC	RPMIYVE	LIG_APCC_ABBAyCdc20_2	0.6507

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75459	P antigen family member 1	LIG_APCC_ABBAyCdc20_2	12:18	RPMIYVE	APC,CDC20,FZR1	0.9803	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons