DegronMD

Uniprot ID: P14136

Source protein: Glial fibrillary acidic protein

Source gene: GFAP

Class: LIG_APCC_ABBAyCdc20_2

Location: 217:223

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6093

ASA_SCORE: 83.6714

COIL: 0.3893

CONS_SCORE: 0.4121

DSS_SCORE: 0.2664

HELIX: 0.063

FCONS_SCORE: 0.7607

RIG_SCORE: 0.8032

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A233E	TCGA-78-8640	LUAD	TCGA	RQQVHVE	LIG_APCC_ABBAyCdc20_2	0.0556
p.A233E	DO45340	LUAD	ICGC	RQQVHVE	LIG_APCC_ABBAyCdc20_2	0.0556
p.D230G	TCGA-AA-3986	COAD	TCGA	RQQVHVE	LIG_APCC_ABBAyCdc20_2	0.1389
p.D230G	DO8216	COAD	ICGC	RQQVHVE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A233T	TCGA-AP-A059	UCEC	TCGA	RQQVHVE	LIG_APCC_ABBAyCdc20_2	0.0556
p.A233T	TCGA-AX-A05Z	UCEC	TCGA	RQQVHVE	LIG_APCC_ABBAyCdc20_2	0.0556
p.A233T	TCGA-B5-A0JY	UCEC	TCGA	RQQVHVE	LIG_APCC_ABBAyCdc20_2	0.0556
p.A233T	DO40884	UCEC	ICGC	RQQVHVE	LIG_APCC_ABBAyCdc20_2	0.0556
p.A233T	DO43041	UCEC	ICGC	RQQVHVE	LIG_APCC_ABBAyCdc20_2	0.0556
p.A233T	DO41361	UCEC	ICGC	RQQVHVE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E223K	TCGA-IB-7651	PAAD	TCGA	RQQVHVE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E223K	DO46657	PAAD	ICGC	RQQVHVE	LIG_APCC_ABBAyCdc20_2	0.7022
p.E210K	TCGA-UD-AAC4	MESO	TCGA	RQQVHVE	LIG_APCC_ABBAyCdc20_2	0.1389
p.D225V	DO222905	BTCA	ICGC	RQQVHVE	LIG_APCC_ABBAyCdc20_2	0.2778
p.V222A	DO234320	ESAD	ICGC	RQQVHVE	LIG_APCC_ABBAyCdc20_2	0.5825
p.L231I	DO228952	LICA	ICGC	RQQVHVE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R209Q	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	RQQVHVE	LIG_APCC_ABBAyCdc20_2	0.1111
p.T232N	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	RQQVHVE	LIG_APCC_ABBAyCdc20_2	0.0833
p.T232N	ACH-000916	Lung Cancer	CCLE	RQQVHVE	LIG_APCC_ABBAyCdc20_2	0.0833
p.T232N	NCI-H1573	lung	COSMIC	RQQVHVE	LIG_APCC_ABBAyCdc20_2	0.0833
p.E223Q	SIDM00949	T-Cell Non-Hodgkin's Lymphoma	GDSC	RQQVHVE	LIG_APCC_ABBAyCdc20_2	0.6744

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P14136	Glial fibrillary acidic protein	LIG_APCC_ABBAyCdc20_2	217:223	RQQVHVE	APC,CDC20,FZR1	0.6093	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons