DegronMD - P14136(GFAP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A233E	TCGA-78-8640	LUAD	TCGA	RQQVHVE	LIG_APCC_ABBAyCdc20_2	217:223	Mutation rewiring degron network	0.0556
p.A233E	DO45340	LUAD	ICGC	RQQVHVE	LIG_APCC_ABBAyCdc20_2	217:223	Mutation rewiring degron network	0.0556
p.R36C	TCGA-85-8277	LUSC	TCGA	TRLSLARMP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.8301
p.R36C	DO26719	LUSC	ICGC	TRLSLARMP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.8301
p.D230G	TCGA-AA-3986	COAD	TCGA	RQQVHVE	LIG_APCC_ABBAyCdc20_2	217:223	Mutation rewiring degron network	0.1389
p.D230G	DO8216	COAD	ICGC	RQQVHVE	LIG_APCC_ABBAyCdc20_2	217:223	Mutation rewiring degron network	0.1389
p.A233T	TCGA-AP-A059	UCEC	TCGA	RQQVHVE	LIG_APCC_ABBAyCdc20_2	217:223	Mutation rewiring degron network	0.0556
p.A233T	TCGA-AX-A05Z	UCEC	TCGA	RQQVHVE	LIG_APCC_ABBAyCdc20_2	217:223	Mutation rewiring degron network	0.0556
p.A233T	TCGA-B5-A0JY	UCEC	TCGA	RQQVHVE	LIG_APCC_ABBAyCdc20_2	217:223	Mutation rewiring degron network	0.0556
p.A233T	DO40884	UCEC	ICGC	RQQVHVE	LIG_APCC_ABBAyCdc20_2	217:223	Mutation rewiring degron network	0.0556
p.A233T	DO43041	UCEC	ICGC	RQQVHVE	LIG_APCC_ABBAyCdc20_2	217:223	Mutation rewiring degron network	0.0556
p.A233T	DO41361	UCEC	ICGC	RQQVHVE	LIG_APCC_ABBAyCdc20_2	217:223	Mutation rewiring degron network	0.0556
p.R30C	TCGA-BR-8368	STAD	TCGA	TRLSLARMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1944
p.R30C	TCGA-D3-A51R	SKCM	TCGA	TRLSLARMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1944
p.R30C	TCGA-EA-A3HS	CESC	TCGA	TRLSLARMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1944
p.R30C	DO6260	CESC	ICGC	TRLSLARMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1944
p.R30C	DO47480	SKCM	ICGC	TRLSLARMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1944
p.R30C	DO47981	STAD	ICGC	TRLSLARMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1944
p.R41L	TCGA-CK-4951	COAD	TCGA	TRLSLARMP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.7316
p.R41L	DO10582	COAD	ICGC	TRLSLARMP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.7316
p.G34A	TCGA-CK-4951	COAD	TCGA	TRLSLARMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.3056
p.G34A	DO10582	COAD	ICGC	TRLSLARMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.3056
p.S38F	TCGA-DA-A1HW	SKCM	TCGA	TRLSLARMP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.7982
p.S38F	DO38129	SKCM	ICGC	TRLSLARMP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.7982
p.E223K	TCGA-IB-7651	PAAD	TCGA	RQQVHVE	LIG_APCC_ABBAyCdc20_2	217:223	Mutation altering degron motif	0.7022
p.E223K	DO46657	PAAD	ICGC	RQQVHVE	LIG_APCC_ABBAyCdc20_2	217:223	Mutation altering degron motif	0.7022
p.G32S	TCGA-IB-7651	PAAD	TCGA	TRLSLARMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.25
p.G32S	DO46657	PAAD	ICGC	TRLSLARMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.25
p.E210K	TCGA-UD-AAC4	MESO	TCGA	RQQVHVE	LIG_APCC_ABBAyCdc20_2	217:223	Mutation rewiring degron network	0.1389
p.R36H	DO222468	BTCA	ICGC	TRLSLARMP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.8244
p.R36H	DO234422	ESAD	ICGC	TRLSLARMP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.8244
p.R36H	DO27947	ORCA	ICGC	TRLSLARMP	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.8244
p.D225V	DO222905	BTCA	ICGC	RQQVHVE	LIG_APCC_ABBAyCdc20_2	217:223	Mutation rewiring degron network	0.2778
p.V222A	DO234320	ESAD	ICGC	RQQVHVE	LIG_APCC_ABBAyCdc20_2	217:223	Mutation altering degron motif	0.5825
p.L231I	DO228952	LICA	ICGC	RQQVHVE	LIG_APCC_ABBAyCdc20_2	217:223	Mutation rewiring degron network	0.1111
p.P33T	DO229006	LICA	ICGC	TRLSLARMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.2778
p.R29L	DO229268	THCA	ICGC	TRLSLARMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1667
p.P33L	SIDM00303	Ovarian Carcinoma	GDSC	TRLSLARMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.2778
p.P33L	ACH-000584	Ovarian Cancer	CCLE	TRLSLARMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.2778
p.R209Q	SIDM01986	Non-Small Cell Lung Carcinoma	GDSC	RQQVHVE	LIG_APCC_ABBAyCdc20_2	217:223	Mutation rewiring degron network	0.1111
p.L46I	SIDM00927	Small Cell Lung Carcinoma	GDSC	TRLSLARMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.25
p.L46I	ACH-000871	Lung Cancer	CCLE	TRLSLARMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.25
p.L46I	NCI-H510A	lung	COSMIC	TRLSLARMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.25
p.T232N	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	RQQVHVE	LIG_APCC_ABBAyCdc20_2	217:223	Mutation rewiring degron network	0.0833
p.T232N	ACH-000916	Lung Cancer	CCLE	RQQVHVE	LIG_APCC_ABBAyCdc20_2	217:223	Mutation rewiring degron network	0.0833
p.T232N	NCI-H1573	lung	COSMIC	RQQVHVE	LIG_APCC_ABBAyCdc20_2	217:223	Mutation rewiring degron network	0.0833
p.E223Q	SIDM00949	T-Cell Non-Hodgkin's Lymphoma	GDSC	RQQVHVE	LIG_APCC_ABBAyCdc20_2	217:223	Mutation altering degron motif	0.6744
p.R49W	SIDM01246	Ewing's Sarcoma	GDSC	TRLSLARMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1667
p.R49W	SIDM00634	Ewing's Sarcoma	GDSC	TRLSLARMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1667
p.R49W	ACH-000039	Bone Cancer	CCLE	TRLSLARMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1667
p.R49W	ACH-002160	Bone Cancer	CCLE	TRLSLARMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1667
p.R49W	MC-IXC	autonomic ganglia	COSMIC	TRLSLARMP	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1667

Kaplan plot for GFAP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GFAP

UniProt ID: P14136

Entrez ID: 2670

Protein name: Glial fibrillary acidic protein (GFAP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GFAP in