DegronMD

Uniprot ID: P14136

Source protein: Glial fibrillary acidic protein

Source gene: GFAP

Class: DEG_APCC_DBOX_1

Location: 35:43

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9836

ASA_SCORE: 69.4333

COIL: 0.7292

CONS_SCORE: 0.3343

DSS_SCORE: 0.5423

HELIX: 0.0839

FCONS_SCORE: 0.7633

RIG_SCORE: 0.7167

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R36C	TCGA-85-8277	LUSC	TCGA	TRLSLARMP	DEG_APCC_DBOX_1	0.8301
p.R36C	DO26719	LUSC	ICGC	TRLSLARMP	DEG_APCC_DBOX_1	0.8301
p.R30C	TCGA-BR-8368	STAD	TCGA	TRLSLARMP	DEG_APCC_DBOX_1	0.1944
p.R30C	TCGA-D3-A51R	SKCM	TCGA	TRLSLARMP	DEG_APCC_DBOX_1	0.1944
p.R30C	TCGA-EA-A3HS	CESC	TCGA	TRLSLARMP	DEG_APCC_DBOX_1	0.1944
p.R30C	DO6260	CESC	ICGC	TRLSLARMP	DEG_APCC_DBOX_1	0.1944
p.R30C	DO47480	SKCM	ICGC	TRLSLARMP	DEG_APCC_DBOX_1	0.1944
p.R30C	DO47981	STAD	ICGC	TRLSLARMP	DEG_APCC_DBOX_1	0.1944
p.R41L	TCGA-CK-4951	COAD	TCGA	TRLSLARMP	DEG_APCC_DBOX_1	0.7316
p.R41L	DO10582	COAD	ICGC	TRLSLARMP	DEG_APCC_DBOX_1	0.7316
p.G34A	TCGA-CK-4951	COAD	TCGA	TRLSLARMP	DEG_APCC_DBOX_1	0.3056
p.G34A	DO10582	COAD	ICGC	TRLSLARMP	DEG_APCC_DBOX_1	0.3056
p.S38F	TCGA-DA-A1HW	SKCM	TCGA	TRLSLARMP	DEG_APCC_DBOX_1	0.7982
p.S38F	DO38129	SKCM	ICGC	TRLSLARMP	DEG_APCC_DBOX_1	0.7982
p.G32S	TCGA-IB-7651	PAAD	TCGA	TRLSLARMP	DEG_APCC_DBOX_1	0.25
p.G32S	DO46657	PAAD	ICGC	TRLSLARMP	DEG_APCC_DBOX_1	0.25
p.R36H	DO222468	BTCA	ICGC	TRLSLARMP	DEG_APCC_DBOX_1	0.8244
p.R36H	DO234422	ESAD	ICGC	TRLSLARMP	DEG_APCC_DBOX_1	0.8244
p.R36H	DO27947	ORCA	ICGC	TRLSLARMP	DEG_APCC_DBOX_1	0.8244
p.P33T	DO229006	LICA	ICGC	TRLSLARMP	DEG_APCC_DBOX_1	0.2778
p.R29L	DO229268	THCA	ICGC	TRLSLARMP	DEG_APCC_DBOX_1	0.1667
p.P33L	SIDM00303	Ovarian Carcinoma	GDSC	TRLSLARMP	DEG_APCC_DBOX_1	0.2778
p.P33L	ACH-000584	Ovarian Cancer	CCLE	TRLSLARMP	DEG_APCC_DBOX_1	0.2778
p.L46I	SIDM00927	Small Cell Lung Carcinoma	GDSC	TRLSLARMP	DEG_APCC_DBOX_1	0.25
p.L46I	ACH-000871	Lung Cancer	CCLE	TRLSLARMP	DEG_APCC_DBOX_1	0.25
p.L46I	NCI-H510A	lung	COSMIC	TRLSLARMP	DEG_APCC_DBOX_1	0.25
p.R49W	SIDM01246	Ewing's Sarcoma	GDSC	TRLSLARMP	DEG_APCC_DBOX_1	0.1667
p.R49W	SIDM00634	Ewing's Sarcoma	GDSC	TRLSLARMP	DEG_APCC_DBOX_1	0.1667
p.R49W	ACH-000039	Bone Cancer	CCLE	TRLSLARMP	DEG_APCC_DBOX_1	0.1667
p.R49W	ACH-002160	Bone Cancer	CCLE	TRLSLARMP	DEG_APCC_DBOX_1	0.1667
p.R49W	MC-IXC	autonomic_ganglia	COSMIC	TRLSLARMP	DEG_APCC_DBOX_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TRLSLARMP

Degron related mutations and impact score

Drug responses associated with GFAP mutations

All proteins holding degron of TRLSLARMP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P14136	Glial fibrillary acidic protein	DEG_APCC_DBOX_1	35:43	TRLSLARMP	APC,CDC20,FZR1	0.9836	More...