DegronMD

Uniprot ID: P17014

Source protein: Zinc finger protein 12

Source gene: ZNF12

Class: LIG_APCC_ABBAyCdc20_2

Location: 101:107

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5269

ASA_SCORE: 114.6429

COIL: 0.6424

CONS_SCORE: 0.431

DSS_SCORE: 0.4813

HELIX: 0.06

FCONS_SCORE: 0.936

RIG_SCORE: 0.8247

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E112K	TCGA-17-Z026	LUAD	TCGA	RQTVFIE	LIG_APCC_ABBAyCdc20_2	0.1944
p.I92L	TCGA-AG-4009	READ	TCGA	RQTVFIE	LIG_APCC_ABBAyCdc20_2	0.0833
p.I92L	DO36961	READ	ICGC	RQTVFIE	LIG_APCC_ABBAyCdc20_2	0.0833
p.N115D	TCGA-BG-A222	UCEC	TCGA	RQTVFIE	LIG_APCC_ABBAyCdc20_2	0.1111
p.P99H	TCGA-DU-6392	LGG	TCGA	RQTVFIE	LIG_APCC_ABBAyCdc20_2	0.2778
p.P99H	DO22237	LGG	ICGC	RQTVFIE	LIG_APCC_ABBAyCdc20_2	0.2778
p.P99T	DO229037	LICA	ICGC	RQTVFIE	LIG_APCC_ABBAyCdc20_2	0.2778
p.E107K	DO231040	LUSC	ICGC	RQTVFIE	LIG_APCC_ABBAyCdc20_2	0.7022
p.T103I	DO232761	PBCA	ICGC	RQTVFIE	LIG_APCC_ABBAyCdc20_2	0.5966
p.T103I	SIDM00660	Colorectal Carcinoma	GDSC	RQTVFIE	LIG_APCC_ABBAyCdc20_2	0.5966
p.T103I	LS-411N	large_intestine	COSMIC	RQTVFIE	LIG_APCC_ABBAyCdc20_2	0.5966
p.T108A	VMRC-MELG	skin	COSMIC	RQTVFIE	LIG_APCC_ABBAyCdc20_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P17014	Zinc finger protein 12	LIG_APCC_ABBAyCdc20_2	101:107	RQTVFIE	APC,CDC20,FZR1	0.5269	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons