DegronMD

Uniprot ID: Q6ZWL3

Source protein: Cytochrome P450 4V2

Source gene: CYP4V2

Class: DEG_APCC_DBOX_1

Location: 296:304

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5492

ASA_SCORE: 25.4111

COIL: 0.1207

CONS_SCORE: 0.4605

DSS_SCORE: 0.3839

HELIX: 0.8107

FCONS_SCORE: 1.5664

RIG_SCORE: 0.8071

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R296C	TCGA-AJ-A23O	UCEC	TCGA	RRAFLDLLL	DEG_APCC_DBOX_1	0.719
p.R296C	DO43290	UCEC	ICGC	RRAFLDLLL	DEG_APCC_DBOX_1	0.719
p.R296C	SIDM00181	Bladder Carcinoma	GDSC	RRAFLDLLL	DEG_APCC_DBOX_1	0.719
p.R296C	SIDM01646	Non-Cancerous	GDSC	RRAFLDLLL	DEG_APCC_DBOX_1	0.719
p.R296C	ACH-002358	Non-Cancerous	CCLE	RRAFLDLLL	DEG_APCC_DBOX_1	0.719
p.E310K	TCGA-BS-A0UV	UCEC	TCGA	RRAFLDLLL	DEG_APCC_DBOX_1	0.1667
p.E310K	DO42793	UCEC	ICGC	RRAFLDLLL	DEG_APCC_DBOX_1	0.1667
p.R313S	DO229032	LICA	ICGC	RRAFLDLLL	DEG_APCC_DBOX_1	0.0833
p.P291S	DO220898	MELA	ICGC	RRAFLDLLL	DEG_APCC_DBOX_1	0.1944
p.G288R	ACH-000923	Lymphoma	CCLE	RRAFLDLLL	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZWL3	Cytochrome P450 4V2	DEG_APCC_DBOX_1	296:304	RRAFLDLLL	APC,CDC20,FZR1	0.5492	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons